Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth : The Hokkaido Study on Environment and Children's Health

Miura, Ryu; Ikeda-Araki, Atsuko; Ishihara, Toru; Miyake, Kunio; Miyashita, Chihiro; Nakajima, Tamie; Kobayashi, Sumitaka; Ishizuka, Mayumi; Kubota, Takeo; Kishi, Reiko

Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth : The Hokkaido Study on Environment and Children's Health

Miura, Ryu; Ikeda-Araki, Atsuko; Ishihara, Toru et al.

Science of the total environment, 2021, 783, 147035

Permalink : https://hdl.handle.net/2115/90324

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アクセス権	open access
URI	https://hdl.handle.net/2115/90324
タイトル	Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth : The Hokkaido Study on Environment and Children's Health
著者	Miura, Ryu ; Ikeda-Araki, Atsuko ; Ishihara, Toru ; Miyake, Kunio ; Miyashita, Chihiro ; Nakajima, Tamie ; Kobayashi, Sumitaka ; Ishizuka, Mayumi ; Kubota, Takeo ; Kishi, Reiko
e-Rad_Researcher 20506414 著者名 Miura, Ryu
著者名 Ikeda-Araki, Atsuko
著者名 Ishihara, Toru
著者名 Miyake, Kunio
著者名 Miyashita, Chihiro
著者名 Nakajima, Tamie
著者名 Kobayashi, Sumitaka
著者名 Ishizuka, Mayumi
著者名 Kubota, Takeo
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	EWAS
	DEHP
	MEHP
	Increased methylation
	Ponderal index
発行日	2021-08-20
出版者	Elsevier
収録物名	Science of the total environment
巻(号)	783
ページ	147035
抄録	Prenatal exposure to phthalates negatively affects the offspring's health. In particular, epigenetic alterations, such as DNA methylation, may connect phthalate exposure with health outcomes. Here, we evaluated the association of di-2-ethylhexyl phthalate (DEHP) exposure in utero with cord blood epigenome-wide DNA methylation in 203 mother-child pairs enrolled in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation450 BeadChip. Epigenome-wide association analysis demonstrated the predominant positive associations between the levels of the primary metabolite of DEHP, mono(2-ethylhexyl) phthalate (MEHP), in maternal blood and DNA methylation levels in cord blood. The genes annotated to the CpGs positively associated with MEHP levels were enriched for pathways related to metabolism, the endocrine system, and signal transduc-tion. Among them, methylation levels of CpGs involved in metabolism were inversely associated with the offspring's ponderal index (PI). Further, clustering and mediation analyses suggested that multiple increased methylation changes may jointly mediate the association of DEHP exposure in utero with the offspring's PI at birth. Although further studies are required to assess the impact of these changes, this study suggests that differential DNA methylation may link phthalate exposure in utero to fetal growth and further imply that DNA methylation has predictive value for the offspring's obesity. (c) 2021 Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2021.147035