Various factors contribute to death in patients with different types of pulmonary hypertension : A retrospective pilot study from a single tertiary center

Nakamura, Junichi; Tsujino, Ichizo; Ohira, Hiroshi; Nakaya, Toshitaka; Sugimoto, Ayako; Sato, Takahiro; Watanabe, Taku; Suzuki, Masaru; Kato, Masaru; Yokota, Isao; Konno, Satoshi

Various factors contribute to death in patients with different types of pulmonary hypertension : A retrospective pilot study from a single tertiary center

Nakamura, Junichi; Tsujino, Ichizo; Ohira, Hiroshi et al.

Respiratory Investigation, 2022, 60(5), 647-657

Permalink : https://hdl.handle.net/2115/90333

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アクセス権	open access
URI	https://hdl.handle.net/2115/90333
タイトル	Various factors contribute to death in patients with different types of pulmonary hypertension : A retrospective pilot study from a single tertiary center
著者	Nakamura, Junichi ; Tsujino, Ichizo ; Ohira, Hiroshi ; Nakaya, Toshitaka ; Sugimoto, Ayako ; Sato, Takahiro ; Watanabe, Taku ; Suzuki, Masaru ; Kato, Masaru ; Yokota, Isao ; Konno, Satoshi
著者名 Nakamura, Junichi
e-Rad_Researcher 00344507 著者名 Tsujino, Ichizo
e-Rad_Researcher 20528301 著者名 Ohira, Hiroshi
著者名 Nakaya, Toshitaka
著者名 Sugimoto, Ayako
著者名 Sato, Takahiro
著者名 Watanabe, Taku
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
著者名 Kato, Masaru
e-Rad_Researcher 20761414 著者名 Yokota, Isao
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Right heart failure
	Sudden death
	Cancer
	Respiratory failure
発行日	2022-09
出版者	Elsevier
収録物名	Respiratory Investigation
巻(号)	60(5)
ページ	647-657
抄録	Background: A few studies have focused on the cause of death from different types of pulmonary hypertension (PH). This study aimed to systematically analyze the primary and secondary causes of death and compare the profiles between different PH groups. Methods: The contribution of PH to death was assessed in precapillary PH (i.e., group 1 [pulmonary arterial hypertension], group 3 [PH associated with lung disease], and group 4 [chronic thromboembolic PH]) using specific criteria; death was classified into three categories: PH death (death due to PH only), PH-related death, and PH-unrelated death. Disorders other than PH that contributed to death were analyzed, and mortality profiles were compared between groups. Results: Eighty deceased patients with PH were examined (group 1, n = 28; group 3, n = 39; and group 4, n = 13). The contribution of PH to death was significantly different between the three groups. PH death was most common in group 1 (61%), PH-related death in group 3 (56%), and PH-related death and PH-unrelated death in group 4 (38% for both). The highest contributing factor to death other than PH was respiratory failure in group 3 and malignant disease in group 4. Conclusions: Significant variations in the causes of death were observed in groups 1, 3, and 4 PH patients. In addition to PH, respiratory failure and malignant disease significantly contributed to death in group 3 and group 4 PH, respectively. Understanding the precise death cause may be important in achieving better outcomes in PH patients. (C) 2022 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2212-5345
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.resinv.2022.05.001