Immunolocalization of endomucin-reactive blood vessels and a-smooth muscle actin-positive cells in murine nasal conchae

Maruoka, Haruhi; Hasegawa, Tomoka; Yoshino, Hirona; Abe, Miki; Haraguchi-Kitakamae, Mai; Yamamoto, Tomomaya; Hongo, Hiromi; Nakanishi, Ko; Nasoori, Alireza; Nakajima, Yuhi; Omaki, Masayuki; Sato, Yoshiaki; Luiz de Freitas, Paulo Henrique; Li, Minqi

Immunolocalization of endomucin-reactive blood vessels and a-smooth muscle actin-positive cells in murine nasal conchae

Maruoka, Haruhi; Hasegawa, Tomoka; Yoshino, Hirona et al.

Journal of oral biosciences, 2022, 64(3), 337-345

Permalink : https://hdl.handle.net/2115/90420

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アクセス権	open access
URI	https://hdl.handle.net/2115/90420
タイトル	Immunolocalization of endomucin-reactive blood vessels and a-smooth muscle actin-positive cells in murine nasal conchae
著者	Maruoka, Haruhi ; Hasegawa, Tomoka ; Yoshino, Hirona ; Abe, Miki ; Haraguchi-Kitakamae, Mai ; Yamamoto, Tomomaya ; Hongo, Hiromi ; Nakanishi, Ko ; Nasoori, Alireza ; Nakajima, Yuhi ; Omaki, Masayuki ; Sato, Yoshiaki ; Luiz de Freitas, Paulo Henrique ; Li, Minqi
e-Rad_Researcher 40962577 著者名 Maruoka, Haruhi
e-Rad_Researcher 50739349 著者名 Hasegawa, Tomoka
著者名 Yoshino, Hirona
著者名 Abe, Miki
著者名 Haraguchi-Kitakamae, Mai
e-Rad_Researcher 50928299 著者名 Yamamoto, Tomomaya
e-Rad_Researcher 00778970 著者名 Hongo, Hiromi
e-Rad_Researcher 00754863 著者名 Nakanishi, Ko
e-Rad_Researcher 70910909 著者名 Nasoori, Alireza
著者名 Nakajima, Yuhi
著者名 Omaki, Masayuki
e-Rad_Researcher 00250465 著者名 Sato, Yoshiaki
著者名 Luiz de Freitas, Paulo Henrique
e-Rad_Researcher 60447612 著者名 Li, Minqi
言語	英語
キーワード	Nasal bone
	Blood vessel
	Endomucin
	Alpha smooth muscle actin
発行日	2022-09-19
出版者	Elsevier
収録物名	Journal of oral biosciences
巻(号)	64(3)
ページ	337-345
抄録	Objectives: Recently, the biological functions of endomucin-positive blood vessels and closely associated aSMA-positive cells in long bones have been highlighted. The surrounding tissues of the flat bones, such as nasal bones covered with mucosa and lamina propria, are different from those of the long bones, indicating the different distributions of endomucin-positive blood vessels and aSMA-reactive cells in nasal bones. This study demonstrates the immunolocalization of endomucin-reactive blood vessels and aSMA-positive cells in the nasal conchae of 3- and 7-week-old mice. Methods: The nasal conchae of 3-week-old and 7-week-old male C57BL/6J mice were used for immunoreaction of endomucin, CD34, PDGFbb, TRAP, and c-kit. Results: While we identified abundant endomucin-reactive blood vessels in the lamina propria neighboring the bone, not all were positive for endomucin. More CD34-reactive cells and small blood vessels were observed in the nasal conchae of 3-week-old mice than in those of 7-week-old mice. Some aSMApositive cells in the nasal conchae surrounded the blood vessels, indicating vascular smooth muscle cells, while other aSMA-immunopositive fibroblastic cells were detected throughout the lamina propria. aSMA-positive cells did not co-localize with c-kit-immunoreactivity, thereby indicating that the aSMApositive cells may be myofibroblasts rather than undifferentiated mesenchymal cells. Conclusions: Unlike long bones, nasal conchae contain endomucin-positive as well as endomucinnegative blood vessels and exhibit numerous aSMA-positive fibroblastic cells throughout the lamina propria neighboring the bone. Apparently, the distribution patterns of endomucin-positive blood vessels and aSMA-positive cells in nasal conchae are different from those in long bones. (c) 2022 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1349-0079
関連情報	PMID 35589073
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.job.2022.05.001