Lead concentrations and isotope ratios in blood, breastmilk and feces : contribution of both lactation and soil/dust exposure to infants in a lead

Toyomaki, Haruya; Yabe, John; Nakayama, Shouta M. M.; Yohannes, Yared B.; Muzandu, Kaampwe; Mufune, Tiza; Nakata, Hokuto; Ikenaka, Yoshinori; Kuritani, Takeshi; Nakagawa, Mitsuhiro; Choongo, Kennedy; Ishizuka, Mayumi

Lead concentrations and isotope ratios in blood, breastmilk and feces : contribution of both lactation and soil/dust exposure to infants in a lead

Toyomaki, Haruya; Yabe, John; Nakayama, Shouta M. M. et al.

Environmental pollution, 2021, 286, 117456

Permalink : https://hdl.handle.net/2115/90474

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/90474
タイトル	Lead concentrations and isotope ratios in blood, breastmilk and feces : contribution of both lactation and soil/dust exposure to infants in a lead
著者	Toyomaki, Haruya ; Yabe, John ; Nakayama, Shouta M. M. ; Yohannes, Yared B. ; Muzandu, Kaampwe ; Mufune, Tiza ; Nakata, Hokuto ; Ikenaka, Yoshinori ; Kuritani, Takeshi ; Nakagawa, Mitsuhiro ; Choongo, Kennedy ; Ishizuka, Mayumi
著者名 Toyomaki, Haruya
著者名 Yabe, John
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Yohannes, Yared B.
著者名 Muzandu, Kaampwe
著者名 Mufune, Tiza
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Kuritani, Takeshi
e-Rad_Researcher 50217684 著者名 Nakagawa, Mitsuhiro
著者名 Choongo, Kennedy
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Lead poisoning
	Infant
	Mother
	Breastmilk
	Lead stable isotope
発行日	2021-10-01
出版者	Elsevier
収録物名	Environmental pollution
巻(号)	286
ページ	117456
抄録	Lead (Pb) poses a serious public health concern. Breastmilk may be a possible source of Pb exposure in infants, as Pb can be transferred from the maternal blood to breastmilk. The present study was undertaken to determine the Pb exposure and the contribution of lactation as one of the exposure pathways to infants in a Pb mining area, Kabwe, Zambia. Blood, breastmilk and infants' feces were collected from 418 pairs of infants and mothers. The Pb concentrations, isotope ratios in the samples, and biochemistry in mothers' plasma were analyzed. The overall mean of blood lead levels (BLLs) in infants and mothers were 18.0 and 11.3 mu g/dL, respectively. High Pb concentration in breastmilk (range: 0.4-51.9, mean: 5.3 mu g/L) above the WHO acceptable level between 2 and 5 mu g/ L were found and could be one of the sources of Pb exposure in infants. The Pb isotope ratios in infants' feces were the most similar to Pb ratios in the soil samples. The results suggest that infants are also exposed to Pb from the environment. Pb exposure in infants through breastfeeding and soil ingestion could potentially exceed daily intake of Pb which causes neurodevelopmental toxicity. In contrast to the high BLLs in mothers, the plasma biochemical profiles of most analyzed parameters were interestingly within, or close to, the standard reference values. Our data suggest that environmental remediation is urgently needed to reduce the Pb exposure in infants and mothers from the environment in Kabwe in parallel with chelation therapy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0269-7491
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envpol.2021.117456