Biological behavior of myoepithelial cells in the regeneration of rat atrophied sublingual glands following release from duct ligation

Takahashi, S.; Kohgo, T.; Nakamura, S.; Arambawatta, A. K. S.; Domon, T.; Wakita, M.

Biological behavior of myoepithelial cells in the regeneration of rat atrophied sublingual glands following release from duct ligation

Takahashi, S.; Kohgo, T.; Nakamura, S. et al.

Journal of Molecular Histology, 2005, 36(5), 373-379

Permalink : https://hdl.handle.net/2115/905

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アクセス権	open access
URI	https://hdl.handle.net/2115/905
タイトル	Biological behavior of myoepithelial cells in the regeneration of rat atrophied sublingual glands following release from duct ligation
著者	Takahashi, S. ; Kohgo, T. ; Nakamura, S. ; Arambawatta, A. K. S. ; Domon, T. ; Wakita, M.
e-Rad_Researcher 70241338 著者名 Takahashi, S. 高橋, 茂
著者名 Kohgo, T.
著者名 Nakamura, S.
著者名 Arambawatta, A. K. S.
e-Rad_Researcher 50217618 著者名 Domon, T.
著者名 Wakita, M.
言語	英語
キーワード	parotid-gland
	submandibular-glands
	salivary-glands
	nuclear antigen
	proliferation
	aportosis
	differentiation
	sialandenitis
	mitosis
	death
発行日	2005-11-09
出版者	Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
収録物名	Journal of Molecular Histology
巻(号)	36(5)
ページ	373-379
抄録	The present study aimed to clarify how myoepithelial cells behave during regeneration of an atrophied sublingual gland by investigating cell proliferation and ultrastructure. Atrophy of rat sublingual glands was induced by unilateral ligation of the excretory duct near the hilum with metal clips, which were then removed after one week of ligation for regeneration. The sublingual glands 0–14 days after unligation were examined with single immunohistochemistry for actin as a marker of myoepithelial cells, double immunohistochemistry for actin and proliferating cell nuclear antigen (PCNA) as a marker of proliferating cells, and transmission electron microscopy (TEM). The single immunohistochemistry and TEM showed that myoepithelial cells surrounded residual ducts in the atrophied glands and immature and mature acini in the regenerating glands. Although PCNA-positive myoepithelial cells were identified during regeneration, PCNA labeling indices of myoepithelial cells were low at all time points except at day 7. Ultrastructurally, myoepithelial cells showing bizarre shaped structures in the atrophy changed with maturation of differentiating acinar cells and appeared normal in the regenerated glands. There was no differentiation of the remaining duct cells to myoepithelial cells. These observations suggest that proliferation of myoepithelial cells and differentiation to myoepithelial cells do not commonly participate in the regeneration of atrophied sublingual glands and that the bizarre shaped myoepithelial cells in the atrophied sublingual glands recover the original shapes with acinar cell regeneration.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	1567-2379
EISSN	1573-6865
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10735-005-9009-2