Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk.

Furugen, Ayako; Nishimura, Ayako; Umazume, Takeshi et al.

Journal of pharmaceutical health care and sciences, 2023, 9, 26

Permalink : https://hdl.handle.net/2115/90569

このアイテムのアクセス数:941件（2026-01-17 04:33 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.1186/s40780-023-00295-w     4

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
metadata only access
URI
https://hdl.handle.net/2115/90569
タイトル
Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk.
著者
Furugen, Ayako ; Nishimura, Ayako ; Umazume, Takeshi ; Ishikawa, Hina ; Narumi, Katsuya ; Kobayashi, Masaki
e-Rad_Researcher
90767261
著者名
Furugen, Ayako
著者名
Nishimura, Ayako
e-Rad_Researcher
00807935
著者名
Umazume, Takeshi
著者名
Ishikawa, Hina
e-Rad_Researcher
90746752
著者名
Narumi, Katsuya
e-Rad_Researcher
70431319
著者名
Kobayashi, Masaki
言語
英語
キーワード
Breast milk
Lacosamide
Milk to plasma ratio
Relative infant dose
UPLC/MS/MS
発行日
2023-09-01
出版者
BioMed Central
収録物名
Journal of pharmaceutical health care and sciences
巻(号)
9
ページ
26
抄録
Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk. To facilitate studies on the safety of lacosamide use during breastfeeding, we aimed to develop a method to quantify lacosamide in human breast milk and plasma using ultra-performance liquid chromatography/tandem mass spectrometry.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2055-0294
関連情報
PMID
37653499
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s40780-023-00295-w