Isolation and characterization of an orthoreovirus from Indonesian fruit bats

Intaruck, Kittiya; Itakura, Yukari; Kishimoto, Mai; Chambaro, Herman M.; Setiyono, Agus; Handharyani, Ekowati; Uemura, Kentaro; Harima, Hayato; Taniguchi, Satoshi; Saijo, Masayuki; Kimura, Takashi; Orba, Yasuko; Sawa, Hirofumi; Sasaki, Michihito

Isolation and characterization of an orthoreovirus from Indonesian fruit bats

Intaruck, Kittiya; Itakura, Yukari; Kishimoto, Mai et al.

Virology, 2022, 575, 10-19

Permalink : https://hdl.handle.net/2115/90622

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/90622
タイトル	Isolation and characterization of an orthoreovirus from Indonesian fruit bats
著者	Intaruck, Kittiya ; Itakura, Yukari ; Kishimoto, Mai ; Chambaro, Herman M. ; Setiyono, Agus ; Handharyani, Ekowati ; Uemura, Kentaro ; Harima, Hayato ; Taniguchi, Satoshi ; Saijo, Masayuki ; Kimura, Takashi ; Orba, Yasuko ; Sawa, Hirofumi ; Sasaki, Michihito
著者名 Intaruck, Kittiya
著者名 Itakura, Yukari
著者名 Kishimoto, Mai
著者名 Chambaro, Herman M.
著者名 Setiyono, Agus
著者名 Handharyani, Ekowati
著者名 Uemura, Kentaro
著者名 Harima, Hayato
著者名 Taniguchi, Satoshi
著者名 Saijo, Masayuki
著者名 Kimura, Takashi
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
言語	英語
キーワード	Orthoreovirus
	Nelson bay orthoreovirus
	Indonesia
	Fruit bats
	Virus isolation
	Viral pathogenicity
発行日	2022-10
出版者	Elsevier
収録物名	Virology
巻(号)	575
ページ	10-19
抄録	Nelson Bay orthoreovirus (NBV) is an emerging bat-borne virus and causes respiratory tract infections in humans sporadically. Over the last two decades, several strains genetically related to NBV were isolated from humans and various bat species, predominantly in Southeast Asia (SEA), suggesting a high prevalence of the NBV species in this region. In this study, an orthoreovirus (ORV) belonging to the NBV species was isolated from Indonesian fruit bats' feces, tentatively named Paguyaman orthoreovirus (PgORV). Serological studies revealed that 81.2% (108/ 133) of Indonesian fruit bats sera had neutralizing antibodies against PgORV. Whole-genome sequencing and phylogenetic analysis of PgORV suggested the occurrence of past reassortments with other NBV strains isolated in SEA, indicating the dispersal and circulation of NBV species among bats in this region. Intranasal PgORV inoculation of laboratory mice caused severe pneumonia. Our study characterized PgORV's unique genetic background and highlighted the potential risk of PgORV-related diseases in Indonesia.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2002. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0042-6822
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.virol.2022.08.003