open access

https://hdl.handle.net/2115/90657

Native Amide-Directed C(sp3)−H Amidation Enabled by Electron-Deficient RhIII Catalyst and Electron-Deficient 2-Pyridone Ligand

英語

rhodium

2022-10-28

Wiley-Blackwell

Angewandte chemie-international edition

61(52)

e202213659

Trivalent group-9 metal catalysts with a cyclopentadienyl-type ligand (CpMIII; M=Co, Rh, Ir, Cp=cyclopentadienyl) have been widely used for directed C-H functionalizations, albeit that their application to challenging C(sp(3))-H functionalizations suffers from the limitations of the available directing groups. In this report, we describe directed C(sp(3))-H amidation reactions of simple amide substrates with a variety of substituents. The combination of an electron-deficient (CpRh)-Rh-E catalyst (Cp-E=1,3-bis(ethoxycarbonyl)-substituted Cp) and an electron-deficient 2-pyridone ligand is essential for high reactivity.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Native Amide-Directed C(sp3)–H Amidation Enabled by Electron- Deficient Rh(III) Catalyst and Electron-Deficient 2-Pyridone Ligand, which has been published in final form at 10.1002/anie.202213659. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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