Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP : a nested case-control study

Yoshimura, Masaru; Fujieda, Yuichiro; Sugawara, Masanari; Kono, Michihito; Kato, Masaru; Yokota, Isao; Amengual, Olga; Ito, Yoichi M.; Atsumi, Tatsuya

Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP : a nested case-control study

Yoshimura, Masaru; Fujieda, Yuichiro; Sugawara, Masanari et al.

Rheumatology international, 2022, 42(11), 1939-1946

Permalink : https://hdl.handle.net/2115/90684

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アクセス権	open access
URI	https://hdl.handle.net/2115/90684
タイトル	Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP : a nested case-control study
著者	Yoshimura, Masaru ; Fujieda, Yuichiro ; Sugawara, Masanari ; Kono, Michihito ; Kato, Masaru ; Yokota, Isao ; Amengual, Olga ; Ito, Yoichi M. ; Atsumi, Tatsuya
著者名 Yoshimura, Masaru
e-Rad_Researcher 70790872 著者名 Fujieda, Yuichiro
著者名 Sugawara, Masanari
e-Rad_Researcher 00835192 著者名 Kono, Michihito
e-Rad_Researcher 10755896 著者名 Kato, Masaru
e-Rad_Researcher 20761414 著者名 Yokota, Isao
e-Rad_Researcher 10636939 著者名 Amengual, Olga
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Rheumatoid arthritis
	Venous thromboembolism
	Disease activity
	Time-averaged DAS28CRP
発行日	2022-11-01
出版者	Springer
収録物名	Rheumatology international
巻(号)	42(11)
ページ	1939-1946
抄録	The objective of this study is to clarify the clinical features and risk factors of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). We retrospectively reviewed the prevalence of VTE in RA patients who visited Hokkaido University Hospital from 2010 to 2019 and had more than 2 years of follow-up. To explore the risk to develop VTE, we selected 260 RA patients without VTE (non-VTE) via density sampling and identified the risk factors for VTE by multivariate logistic regression analysis. Univariate conditional logistic regression analysis showed older age (p < 0.0001, Odds Ratio [OR] 1.08, 95% Confidence Interval [CI] 1.04-1.14), increase of the body mass index (BMI) (p = 0.001, OR 1.17, 95% CI 1.06-1.31), higher prevalence of RA-associated lung disease (p = 0.002, OR 2.10, 95% CI 1.33-3.30) and more frequent glucocorticoid usage (p = 0.001, OR 2.09, 95% CI 1.34-3.51) in RA patients was associated with the development of VTE significantly. Furthermore, patients with higher time-averaged disease activity score 28 (DAS28) CRP were at elevated risk (p < 0.0001, OR 3.25, 95% CI 1.94-6.12). In conditional multivariate logistic regression analysis, time averaged DAS28CRP was significantly associated with the development of VTE (p = 0.0001, adjusted OR 3.40, 95% CI 1.77-7.85). Disease activity was identified as a major risk factor of VTE in patients with RA, suggesting that sustained clinical remission could be beneficial for decrease the risk of VTE.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00296-022-05121-4
PISSN	0172-8172
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00296-022-05121-4