Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis

Tsujino, Dai; Yoshii, Kentaro; Kajiyama, Misa; Takahashi, Yuji; Maekawa, Naoya; Kariwa, Hiroaki; Kobayashi, Shintaro

Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis

Tsujino, Dai; Yoshii, Kentaro; Kajiyama, Misa et al.

Virus Research, 2022, 321, 198914

Permalink : https://hdl.handle.net/2115/90730

このアイテムのアクセス数:897件（2026-08-08 22:19 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/90730
タイトル	Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis
著者	Tsujino, Dai ; Yoshii, Kentaro ; Kajiyama, Misa ; Takahashi, Yuji ; Maekawa, Naoya ; Kariwa, Hiroaki ; Kobayashi, Shintaro
著者名 Tsujino, Dai
著者名 Yoshii, Kentaro
著者名 Kajiyama, Misa
著者名 Takahashi, Yuji
著者名 Maekawa, Naoya
e-Rad_Researcher 70224714 著者名 Kariwa, Hiroaki
e-Rad_Researcher 00634205 著者名 Kobayashi, Shintaro
言語	英語
キーワード	Tick-borne encephalitis virus
	Programmed cell death
	Necroptosis
発行日	2022-11
出版者	Elsevier
収録物名	Virus Research
巻(号)	321
ページ	198914
抄録	Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes tick-borne encephalitis (TBE) in humans. Infections of Sapporo-17-Io1 (Sapporo) and Oshima 5-10 (Oshima) TBEV strains showed different pathogenic effects in mice. However, the differences between the two strains are unknown. In this study, we examined neuronal degeneration and death, and activation of glial cells in mice inoculated with each strain to investigate the pathogenesis of TBE. Viral growth was similar between Sapporo and Oshima, but neuronal degeneration and death, and activation of glial cells, was more prominent with Oshima. In human neuroblastoma cells, apoptosis and pyroptosis were not observed after TBEV infection. However, the expression of the necroptosis marker, mixed lineage kinase domain-like (MLKL) protein, was upregulated by TBEV infection, and this upregulation was more pronounced in Oshima than Sapporo infections. As necroptosis is a pro-inflammatory type of cell death, differences in necroptosis induction might be involved in the differences in neuropathogenicity of TBE.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0168-1702
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.virusres.2022.198914