open access

https://hdl.handle.net/2115/90945

Detection of sentinel lymph node with a novel near-infrared fluorescence spectrum system and indocyanine green fluorescence in patients with early breast cancer : First clinical experience

英語

Fluorescence spectroscopy

2022-12

Elsevier

Photodiagnosis and photodynamic therapy

40

103061

Background: Sentinel lymph node biopsy (SLNB) for early breast cancer is common, and many studies have re-ported its usefulness with indocyanine green (ICG). However, in the case of sentinel lymph node (SNs) identi-fication using ICG, it is difficult to accurately identify the fluorescence signal of SNs through the skin because of the weakening of the signal due to the intervening tissue thickness. In this study, we examined whether fluo-rescence spectroscopy can detect weaker fluorescence signals and accurately identify SNs that have accumulated ICG.Methods: Six women with early breast cancer and clinically confirmed negative axillae were recruited. The periareolar region was subcutaneously injected with ICG (1 ml, 5 mg/mL). The identification rate of SNs in the skin was studied using the novel fluorescence spectroscopy (LumifinderTM, ADVANTEST, Tokyo, Japan).Results: LumifinderTM was able to identify 100% of SNs in the skin (6/6 patients). In addition, for SNs identifi-cation in deeper axillary areas, pressing the probe tip against the body surface allows clearer fluorescence observation.Conclusion: Novel fluorescence spectroscopy (LumifinderTM) may overcome the problem of SLNB using ICG for breast cancer.

学術雑誌論文

Accepted Manuscript

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

1572-1000