Relationship between laparoscopic total gastrectomy-associated postoperative complications and gastric cancer prognosis

Ebihara, Yuma; Kyogoku, Noriaki; Murakami, Yoshihiro; Murakawa, Katsuhiko; Nakamura, Fumitaka; Morita, Takayuki; Okushiba, Shunichi; Hirano, Satoshi

Relationship between laparoscopic total gastrectomy-associated postoperative complications and gastric cancer prognosis

Ebihara, Yuma; Kyogoku, Noriaki; Murakami, Yoshihiro et al.

Updates in surgery, 2023, 75(1), 149-158

Permalink : https://hdl.handle.net/2115/91066

このアイテムのアクセス数:482件（2026-10-11 09:40 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Updates Surg 75 149-158	pdf	683 KB	236

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/91066
タイトル	Relationship between laparoscopic total gastrectomy-associated postoperative complications and gastric cancer prognosis
著者	Ebihara, Yuma ; Kyogoku, Noriaki ; Murakami, Yoshihiro ; Murakawa, Katsuhiko ; Nakamura, Fumitaka ; Morita, Takayuki ; Okushiba, Shunichi ; Hirano, Satoshi
e-Rad_Researcher 50632981 著者名 Ebihara, Yuma
著者名 Kyogoku, Noriaki
著者名 Murakami, Yoshihiro
著者名 Murakawa, Katsuhiko
著者名 Nakamura, Fumitaka
著者名 Morita, Takayuki
著者名 Okushiba, Shunichi
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
言語	日本語
キーワード	Laparoscopic total gastrectomy
	Gastric cancer
	Postoperative complications
	Prognosis
	Overall survival
発行日	2023-01-01
出版者	Springer
収録物名	Updates in surgery
巻(号)	75(1)
ページ	149-158
抄録	This study aimed to investigate the incidence and prognosis of postoperative complications after laparoscopic total gastrectomy (LTG) for gastric cancer (GC). We retrospectively enrolled 411 patients who underwent curative LTG for GC at seven institutions between January 2004 and December 2018. The patients were divided into two groups, complication group (CG) and non-complication group (non-CG), depending on the presence of serious postoperative complications (Clavien-Dindo grade III [>= CD IIIa] or higher complications). Short-term outcomes and prognoses were compared between two groups. Serious postoperative complications occurred in 65 (15.8%) patients. No significant difference was observed between the two groups in the median operative time, intraoperative blood loss, number of lymph nodes harvested, or pathological stage; however, the 5-year overall survival (OS; CG 66.4% vs. non-CG 76.8%; p = 0.001), disease-specific survival (DSS; CG 70.1% vs. non-CG 76.2%; p = 0.011), and disease-free survival (CG 70.9% vs. non-CG 80.9%; p = 0.001) were significantly different. The Cox multivariate analysis identified the serious postoperative complications as independent risk factors for 5-year OS (HR 2.143, 95% CI 1.165-3.944, p = 0.014) and DSS (HR 2.467, 95% CI 1.223-4.975, p = 0.011). A significant difference was detected in the median days until postoperative recurrence (CG 223 days vs. non-CG 469 days; p = 0.017) between the two groups. Serious postoperative complications after LTG negatively affected the GC prognosis. Efforts to decrease incidences of serious complications should be made that may help in better prognosis in patients with GC after LTG.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s13304-022-01402-6
PISSN	2038-131X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s13304-022-01402-6