Solid-Phase Total Synthesis of Sandramycin and Its Analogues

Komatani, Yuya; Momosaki, Kyoka; Katsuyama, Akira; Yamamoto, Kazuki; Kaguchi, Rintaro; Ichikawa, Satoshi

Solid-Phase Total Synthesis of Sandramycin and Its Analogues

Komatani, Yuya; Momosaki, Kyoka; Katsuyama, Akira et al.

Organic letters, 2023, 25(3), 543-548

Permalink : https://hdl.handle.net/2115/91297

このアイテムのアクセス数:362件（2026-01-15 08:14 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Text_sasndramycin_revise_3_combine	pdf	853 KB	1,060

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/91297
タイトル	Solid-Phase Total Synthesis of Sandramycin and Its Analogues
著者	Komatani, Yuya ; Momosaki, Kyoka ; Katsuyama, Akira ; Yamamoto, Kazuki ; Kaguchi, Rintaro ; Ichikawa, Satoshi
著者名 Komatani, Yuya
著者名 Momosaki, Kyoka
e-Rad_Researcher 20824709 著者名 Katsuyama, Akira
著者名 Yamamoto, Kazuki
著者名 Kaguchi, Rintaro
e-Rad_Researcher 60333621 著者名 Ichikawa, Satoshi
言語	英語
発行日	2023-01-18
出版者	American Chemical Society
収録物名	Organic letters
巻(号)	25(3)
ページ	543-548
抄録	Solid-phase total synthesis of sandramycin (1), which is a C2-symmetric cyclic decadepsipeptide natural product, and its analogues is described. On-resin ester formation and [5+5] peptide coupling allowed the preparation of a range of desymmetrized analogues. An amino acid residue that would not hamper the biological activity of 1 was successfully identified, and probe molecules and dimeric analogues were prepared on the basis of the result of the structure-activity relationship study.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-UJZNIRYD6IYBD5B6YGMY.
PISSN	1523-7060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.orglett.2c04327