Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia

Yoshida, Shota; Onozawa, Masahiro; Miyashita, Naoki et al.

International journal of hematology, 2023, 117(4), 544-552

Permalink : https://hdl.handle.net/2115/92070

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アクセス権
open access
URI
https://hdl.handle.net/2115/92070
タイトル
Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia
著者
Yoshida, Shota ; Onozawa, Masahiro ; Miyashita, Naoki ; Kimura, Hiroyuki ; Takahashi, Shogo ; Yokoyama, Shota ; Matsukawa, Toshihiro ; Hirabayashi, Shinsuke ; Mori, Akio ; Hidaka, Daisuke ; Minauchi, Koichiro ; Shigematsu, Akio ; Hashiguchi, Junichi ; Igarashi, Tetsuyuki ; Kakinoki, Yasutaka ; Tsutsumi, Yutaka ; Ibata, Makoto ; Kobayashi, Hajime ; Haseyama, Yoshihito ; Fujimoto, Katsuya ; Ishihara, Toshimichi ; Sakai, Hajime ; Ota, Shuichi ; Kondo, Takeshi ; Teshima, Takanori
著者名
Yoshida, Shota
e-Rad_Researcher
70455632
著者名
Onozawa, Masahiro
著者名
Miyashita, Naoki
著者名
Kimura, Hiroyuki
著者名
Takahashi, Shogo
著者名
Yokoyama, Shota
著者名
Matsukawa, Toshihiro
著者名
Hirabayashi, Shinsuke
著者名
Mori, Akio
著者名
Hidaka, Daisuke
著者名
Minauchi, Koichiro
著者名
Shigematsu, Akio
著者名
Hashiguchi, Junichi
著者名
Igarashi, Tetsuyuki
著者名
Kakinoki, Yasutaka
著者名
Tsutsumi, Yutaka
著者名
Ibata, Makoto
著者名
Kobayashi, Hajime
著者名
Haseyama, Yoshihito
著者名
Fujimoto, Katsuya
著者名
Ishihara, Toshimichi
著者名
Sakai, Hajime
著者名
Ota, Shuichi
著者名
Kondo, Takeshi
e-Rad_Researcher
40284096
著者名
Teshima, Takanori
言語
英語
キーワード
Complex karyotype
CK-AML
Typical CK-AML
Monosomy 17
Deletion of 17p
TP53 mutation
発行日
2023-04-01
出版者
Springer
収録物名
International journal of hematology
巻(号)
117(4)
ページ
544-552
抄録
Complex karyotype acute myeloid leukemia (CK-AML) has been classified as an adverse-risk subtype. Although a few reports have further classified CK-AML as typical (including monosomy of chromosomes 5, 7 and 17 or deletion of 5q, 7q and/or 17p) or atypical, the clinical features of these subtypes in Japanese patients remain unclear. We retrospectively analyzed a total of 115 patients with CK-AML, including 77 with typical CK-AML and 38 with atypical CK-AML. Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.009). Among patients with typical CK-AML, those with monosomy 17 or deletion of 17p had significantly shorter OS than patients without such abnormalities (105 days vs. 165 days, P = 0.033). TP53 mutations were more predominant in patients with typical CK-AML than in patients with atypical CK-AML (69.7% vs. 32.4%, P < 0.001). Patients with typical CK-AML had a poor prognosis regardless of TP53 mutation status. Among patients with atypical CK-AML, however, prognosis was worse for those with the TP53 mutation than those without the mutation. In conclusion, prognosis is extremely poor for both typical CK-AML and atypical CK-AML with TP53 mutation.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-022-03522-6
PISSN
0925-5710
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s12185-022-03522-6