open access

https://doi.org/10.14943/doctoral.k15937

https://hdl.handle.net/2115/92202

AI駆動型形態計測とGISを用いた空間マッピング法の確立によるテリパラチドを連日または週1回投与したイヌ皮質骨リモデリングの評価

英語

Geographical information system

2024-03-25

Hokkaido University

Larger animal models with a well-developed Haversian system, as observed in humans, are ideal to analyze cortical bone remodeling in pharmacological studies of anti-osteoporosis drugs, although they have some limi-tations in controlling individual variability in size, weight, age, and number. This study aimed to morphomet-rically analyze cortical bone remodeling focusing on Haversian canals in dogs using four regimens of TPTD with daily and weekly administrations at lower and higher weekly doses (4.9 μg/kg/week and 19.8 μg/kg/week,respectively) for 9 months. A micro-computed tomography-based analysis showed no significant differences among regimen groups. By establishing artificial intelligence (AI)-driven morphometric analyses and geographical information system (GIS)-based spatial mapping of Haversian canals that does not require confocal microscopy but is possible with more commonly used wide field microscopes, we successfully observed signif-icant morphometric distinctions among regimens applied even in dogs. Our analytical results suggested that the daily higher regimen specifically increased the number of eroded pores creating spaces between existing canals,thus stimulating cortical bone remodeling.

2024-03-25

甲第15937号

博士(歯学)

(主査) 教授 飯村 忠浩, 教授 網塚 憲生, 教授 佐藤 嘉晃

歯学院(口腔医学専攻)

博士論文

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Ⓒ2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)