Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry

Isshiki, Ryota; Kubota, Koji; Ito, Hajime

Synlett, 2023, 34(12), 1419-1424

Permalink : https://hdl.handle.net/2115/92243

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アクセス権	open access
URI	https://hdl.handle.net/2115/92243
タイトル	Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry
著者	Isshiki, Ryota ; Kubota, Koji ; Ito, Hajime
e-Rad_Researcher 70965227 著者名 Isshiki, Ryota
著者名 Kubota, Koji
e-Rad_Researcher 90282300 著者名 Ito, Hajime
言語	英語
キーワード	C-C bond cleavage
	fluorination
	mechanochemistry
	ball-milling
	solid-state chemistry
	silver catalysis
発行日	2023-05-03
出版者	Georg Thieme Verlag
収録物名	Synlett
巻(号)	34(12)
ページ	1419-1424
抄録	In this report, we demonstrate that a ball-milling technique facilitates fast and efficient silver-catalyzed ring-opening fluorination of cyclobutanols. This is the first report of a catalytic C-C bond-cleav-age/functionalization reaction under solid-state mechanochemical con-ditions. The developed protocol affords a high yield of ?-fluorinated ke-tones within much shorter reaction times, and requires less silver catalyst and Selectfluor compared with the previous solution-based conditions. Notably, the process can be carried out in air. Because of the reduced use of chemicals and the simple time-saving experimental pro-cedures, this technique is an efficient and environmentally friendly way to access ?-fluorinated ketones.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0936-5214
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1055/a-2021-9599