Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina
Kageyama, Hiroyuki; Morita, Koichi; Katoh, Chietsugu et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2005, 33(1), 6-12
Permalink : https://hdl.handle.net/2115/923
このアイテムのアクセス数:2,718件（2026-06-14 21:52 集計）
閲覧可能ファイル
| ファイル |
フォーマット |
サイズ |
閲覧回数 |
説明 |
|
EJNMMI33-1
|
pdf
|
329 KB |
1,913
|
|
論文情報
ファイル出力
EndNote Basic出力
Mendeley出力
| アクセス権 |
|
| URI |
|
| タイトル |
|
| 著者 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 言語 |
|
| キーワード |
|
|
|
|
|
|
|
| 発行日 |
|
| 出版者 |
|
| 収録物名 |
|
| 巻(号) |
|
| ページ |
|
| 抄録 |
Purpose Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest, but in ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123I-BMIPP is a radiolabeled LCFA analog. In chronic stable angina without previous infarction, we suppose that reduced 123I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). The purpose of this study was to relate 123I-BMIPP uptake to rest myocardial blood flow (MBF), hyperemic MBF, and MFR assessed with 15O-water positron emission tomography (PET).
Methods We enrolled 21 patients with chronic stable angina without previous infarction, all of whom underwent 123I-BMIPP single-photon emission computed tomography (SPECT) and 15O-water PET. The left ventricle was divided into 13 segments. In each segment, rest MBF and hyperemic MBF were measured by PET. 123I-BMIPP uptake was evaluated as follows: score 0=normal, 1=slightly decreased uptake, 2=moderately decreased uptake, 3=severely decreased uptake, and 4=complete defect. 123I-BMIPP uptake was compared with rest MBF, hyperemic MBF, and MFR.
Results The numbers of segments with 123I-BMIPP scores 0, 1, 2, 3, and 4 were 178, 40, 25, 24, and 0, respectively. The rest MBFs for scores 0, 1, 2, and 3 were 0.93±0.25, 0.86±0.21, 0.97±0.30, and 0.99±0.37 ml/min/g, respectively. The hyperemic MBFs for scores 0, 1, 2, and 3 were 2.76±1.29, 1.84±0.74, 1.37±0.39, and 1.08±0.40 ml/min/g, respectively. The MFRs for scores 0, 1, 2, and 3 were 3.01±1.38, 2.20±0.95, 1.44±0.22, and 1.10±0.26, respectively. As 123I-BMIPP uptake declined, hyperemic MBF and MFR decreased.
Conclusion In chronic stable angina without previous infarction, reduced 123I-BMIPP uptake implies decreased MFR.
|
| 資源タイプ |
|
| 出版タイプ |
|
| 権利情報 |
|
| PISSN |
|
| EISSN |
|
| 関連情報 |
|
| 関連情報 (isVersionOf) |
|
