Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells

Fujino, Shoko; Hamano, Sayuri; Tomokiyo, Atsushi; Sugiura, Risa; Yamashita, Daiki; Hasegawa, Daigaku; Sugii, Hideki; Fujii, Shinsuke; Itoyama, Tomohiro; Miyaji, Hirofumi; Maeda, Hidefumi

Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells

Fujino, Shoko; Hamano, Sayuri; Tomokiyo, Atsushi et al.

Scientific Reports, 2023, 13(1), 5668

Permalink : https://hdl.handle.net/2115/92680

このアイテムのアクセス数:224件（2026-10-08 07:52 集計）

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https://doi.org/10.1038/s41598-023-32126-1			20

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アクセス権	open access
URI	https://hdl.handle.net/2115/92680
タイトル	Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells
著者	Fujino, Shoko ; Hamano, Sayuri ; Tomokiyo, Atsushi ; Sugiura, Risa ; Yamashita, Daiki ; Hasegawa, Daigaku ; Sugii, Hideki ; Fujii, Shinsuke ; Itoyama, Tomohiro ; Miyaji, Hirofumi ; Maeda, Hidefumi
e-Rad_Researcher 60883832 著者名 Fujino, Shoko
著者名 Hamano, Sayuri
e-Rad_Researcher 20507777 著者名 Tomokiyo, Atsushi
著者名 Sugiura, Risa
著者名 Yamashita, Daiki
e-Rad_Researcher 20757992 著者名 Hasegawa, Daigaku
e-Rad_Researcher 80802280 著者名 Sugii, Hideki
e-Rad_Researcher 60452786 著者名 Fujii, Shinsuke
e-Rad_Researcher 50884433 著者名 Itoyama, Tomohiro
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
e-Rad_Researcher 10284514 著者名 Maeda, Hidefumi
言語	英語
発行日	2023-04-06
出版者	Nature
収録物名	Scientific Reports
巻(号)	13(1)
ページ	5668
抄録	Conventional direct pulp-capping materials induce pulp cells to secrete various biomolecules in pulp tissues that promote reparative dentin formation through induction of odontoblastic differentiation of dental pulp stem cells (DPSCs). However, these biomolecules sometimes induce bone-like dentin with poor sealing properties. Therefore, exploration of biomolecules that allow tight sealing by tubular reparative dentin is required. We recently reported that dopamine (DA) is involved in dentinogenesis. Hence, we investigated the effect of DA on odontoblastic differentiation of DPSCs and reparative dentin formation. Both tyrosine hydroxylase (TH), a DA synthetase, and DA were expressed in odontoblast-like cells in vivo. In vitro, their expression was increased during odontoblastic differentiation of DPSCs. Furthermore, TH-overexpressing DPSCs had promoted odontoblastic differentiation and DA production. Moreover, DA stimulation promoted their differentiation and induced tubular reparative dentin. These results suggest that DA produced by TH is involved in odontoblastic differentiation of DPSCs and has an inductive capacity for reparative dentin formation similar to primary dentin. This study may lead to the development of therapy to preserve vital pulp tissues.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報	PMID 37024514
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-023-32126-1