Fragmented QRS on 12-lead electrocardiogram predicts long-term prognosis in patients with cardiac sarcoidosis

Hagiwara, Hikaru; Watanabe, Masaya; Kadosaka, Takahide; Koizumi, Takuya; Kobayashi, Yuta; Koya, Taro; Nakao, Motoki; Tsuneta, Satonori; Kato, Yoshiya; Komoriyama, Hirokazu; Kamada, Rui; Nagai, Toshiyuki; Kudo, Kohsuke; Anzai, Toshihisa

Fragmented QRS on 12-lead electrocardiogram predicts long-term prognosis in patients with cardiac sarcoidosis

Hagiwara, Hikaru; Watanabe, Masaya; Kadosaka, Takahide et al.

Heart and vessels, 2023, 38(6), 803-816

Permalink : https://hdl.handle.net/2115/92732

このアイテムのアクセス数:216件（2026-08-12 03:55 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/92732
タイトル	Fragmented QRS on 12-lead electrocardiogram predicts long-term prognosis in patients with cardiac sarcoidosis
著者	Hagiwara, Hikaru ; Watanabe, Masaya ; Kadosaka, Takahide ; Koizumi, Takuya ; Kobayashi, Yuta ; Koya, Taro ; Nakao, Motoki ; Tsuneta, Satonori ; Kato, Yoshiya ; Komoriyama, Hirokazu ; Kamada, Rui ; Nagai, Toshiyuki ; Kudo, Kohsuke ; Anzai, Toshihisa
著者名 Hagiwara, Hikaru
e-Rad_Researcher 40632047 著者名 Watanabe, Masaya
著者名 Kadosaka, Takahide
著者名 Koizumi, Takuya
著者名 Kobayashi, Yuta
著者名 Koya, Taro
著者名 Nakao, Motoki
著者名 Tsuneta, Satonori
著者名 Kato, Yoshiya
著者名 Komoriyama, Hirokazu
著者名 Kamada, Rui
e-Rad_Researcher 00528218 著者名 Nagai, Toshiyuki
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 60232089 著者名 Anzai, Toshihisa
言語	英語
キーワード	Cardiac sarcoidosis
	Electrocardiography
	Fragmented QRS
	Ventricular arrhythmias
発行日	2023-06-01
出版者	Springer
収録物名	Heart and vessels
巻(号)	38(6)
ページ	803-816
抄録	Fragmented QRS (fQRS) on a 12-lead electrocardiogram is a known marker of fatal arrhythmias or cardiac adverse events in ischemic and non-ischemic cardiomyopathy patients. Nonetheless, the association between fQRS and clinical outcomes in patients with cardiac sarcoidosis (CS) remains unclear. Herein, we investigated whether fQRS is associated with longterm clinical outcomes in CS patients. A total of 78 patients who received immunosuppressive therapy (IST) for clinically diagnosed CS were retrospectively examined. Patients were classified into two groups according to the presence (n = 19) or absence (n = 59) of fQRS on electrocardiogram before IST. The primary outcome was the composite event of all-cause death, ventricular tachyarrhythmias (VTs), and hospitalization for heart failure. Results of late gadolinium enhancement on cardiac magnetic resonance imaging were also analyzed. During a median follow-up period of 3.7 years (interquartile range: 1.6-6.2 years), the primary outcome occurred more frequently in patients with fQRS than in those without (47% vs. 13%, log-rank p = 0.002). Multivariable Cox regression analyses showed that fQRS was an independent determinant of the primary outcome. The incidence of VTs, within 12 months of IST initiation, was comparable between the two groups; however, late-onset VTs, defined as those occurring >= 12 months after IST initiation, occurred more frequently in the fQRS group (21% vs. 2%, log-rank p = 0.002). The scar zone and scar border zone were greater in patients with fQRS than in those without it. In conclusion, our analysis suggests that fQRS is an independent predictor of adverse events, particularly late-onset VTs, in patients with CS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/doi.org/10.1007/s00380-022-02229-2
PISSN	0910-8327
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00380-022-02229-2