Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity

Maeda, Yukari; Hirata, Eri; Takano, Yuta; Sakaguchi, Norihito; Ushijima, Natsumi; Saeki, Ayumi; Kimura, Sadahito; Shibata, Ken-ichiro; Yudasaka, Masako; Yokoyama, Atsuro

Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity

Maeda, Yukari; Hirata, Eri; Takano, Yuta et al.

Carbon, 2020, 166, 36-45

Permalink : https://hdl.handle.net/2115/92848

このアイテムのアクセス数:171件（2026-08-16 05:16 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/92848
タイトル	Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity
著者	Maeda, Yukari ; Hirata, Eri ; Takano, Yuta ; Sakaguchi, Norihito ; Ushijima, Natsumi ; Saeki, Ayumi ; Kimura, Sadahito ; Shibata, Ken-ichiro ; Yudasaka, Masako ; Yokoyama, Atsuro
e-Rad_Researcher 40884622 著者名 Maeda, Yukari
e-Rad_Researcher 10722019 著者名 Hirata, Eri
著者名 Takano, Yuta
e-Rad_Researcher 70344489 著者名 Sakaguchi, Norihito
e-Rad_Researcher 40374558 著者名 Ushijima, Natsumi
e-Rad_Researcher 70638345 著者名 Saeki, Ayumi
e-Rad_Researcher 60910635 著者名 Kimura, Sadahito
e-Rad_Researcher 50145265 著者名 Shibata, Ken-ichiro
e-Rad_Researcher 70159226 著者名 Yudasaka, Masako
e-Rad_Researcher 20210627 著者名 Yokoyama, Atsuro
言語	英語
発行日	2020-09-30
出版者	Elsevier
収録物名	Carbon
巻(号)	166
ページ	36-45
抄録	This work demonstrates that certain medically-approved drugs possess dual functions such that they exhibit intrinsic drug effects and can assist in dispersing carbon nanomaterials. Two types of carbon nanohorns (CNHs) (unoxidized: as-CNH, oxidized: CNHox550) and carbon nanotubes (CNTs) were successfully dispersed in aqueous solutions using minocycline (MC) as a dispersant. Absorption spectra, thermogravimetric analyses and theoretical calculations demonstrated that the MC was attached to the CNHs in these dispersions. The antibacterial activities of these MC/CNH complexes were examined using Streptcoccus mutans and Aggregatibacter actinomycetemcomitans, and the MC/as-CNH complex was found to maintain the same bacterial growth inhibition activity as the original MC. Electron microscopy observations suggested direct contact of the MC/CNH complexes with the bacteria, presumably allowing delivery of the MC. The results obtained from our study demonstrate that drug/nanocarbon complexes have potential applications in drug delivery.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0008-6223
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.carbon.2020.04.040