open access

https://hdl.handle.net/2115/92895

Cis-regulatory evolution underlying the changes in wingless expression pattern associated with wing pigmentation of Drosophila

英語

gene regulatory network

2023-07

John Wiley & Sons

FEBS Letters

597(14)

1837-1847

The co-option of regulatory genes has the potential to play an important role in the evolutionary gain of new traits. However, the changes at the sequence level that underlie such a co-option event are still elusive. We identified the changes in the cis-regulatory sequence of wingless that caused co-option of wingless and led to its expression in new places in Drosophila guttifera, which has unique pigmentation patterns on its wings. The newly gained function of gene expression activation was acquired evolutionarily via a combination of pre-existing sequences containing a putative binding site for SMAD transcription factors that exhibit an ancestral function in driving expression at crossveins, and a sequence that is specific to the lineage leading to D. guttifera.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Takumi Karasawa, Namiho Saito, Shigeyuki Koshikawa. (2023) "Cis-regulatory evolution underlying the changes in wingless expression pattern associated with wing pigmentation of Drosophila", FEBS Letters 597(14) 1837-1847, which has been published in final form at https://doi.org/10.1002/1873-3468.14637. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

0014-5793

1873-3468