Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Kato, Izumi; Ogawa, Yudai; Yakushiji, Fumika et al.

Chemical communications, 2023, 59(82), 12306-12309

Permalink : https://hdl.handle.net/2115/93038

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アクセス権
open access
URI
https://hdl.handle.net/2115/93038
タイトル
Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease
著者
Kato, Izumi ; Ogawa, Yudai ; Yakushiji, Fumika ; Ogura, Jiro ; Kobayashi, Masaki ; Shindo, Naoya ; Ichikawa, Satoshi ; Maenaka, Katsumi ; Sakaitani, Masahiro
著者名
Kato, Izumi
著者名
Ogawa, Yudai
e-Rad_Researcher
40548476
著者名
Yakushiji, Fumika
e-Rad_Researcher
20580640
著者名
Ogura, Jiro
e-Rad_Researcher
70431319
著者名
Kobayashi, Masaki
著者名
Shindo, Naoya
e-Rad_Researcher
60333621
著者名
Ichikawa, Satoshi
e-Rad_Researcher
10322752
著者名
Maenaka, Katsumi
著者名
Sakaitani, Masahiro
言語
英語
発行日
2023-09-04
出版者
Royal Society of Chemistry
収録物名
Chemical communications
巻(号)
59(82)
ページ
12306-12309
抄録
A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8 ''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease. A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8 ''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1359-7345
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1039/d3cc03069e