Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots : Investigating Pb exposure in wild birds

Sato, Hiroshi; Ishii, Chihiro; Nakayama, Shouta M. M.; Ichise, Takahiro; Saito, Keisuke; Watanabe, Yukiko; Ogasawara, Kohei; Torimoto, Ryota; Kobayashi, Atsushi; Kimura, Takashi; Nakamura, Yukiko; Yamagishi, Junya; Ikenaka, Yoshinori; Ishizuka, Mayumi

Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots : Investigating Pb exposure in wild birds

Sato, Hiroshi; Ishii, Chihiro; Nakayama, Shouta M. M. et al.

Environmental pollution, 2022, 308, 119580

Permalink : https://hdl.handle.net/2115/93078

このアイテムのアクセス数:208件（2026-08-13 19:03 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Manuscript_clear	pdf	845 KB	87

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/93078
タイトル	Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots : Investigating Pb exposure in wild birds
著者	Sato, Hiroshi ; Ishii, Chihiro ; Nakayama, Shouta M. M. ; Ichise, Takahiro ; Saito, Keisuke ; Watanabe, Yukiko ; Ogasawara, Kohei ; Torimoto, Ryota ; Kobayashi, Atsushi ; Kimura, Takashi ; Nakamura, Yukiko ; Yamagishi, Junya ; Ikenaka, Yoshinori ; Ishizuka, Mayumi
著者名 Sato, Hiroshi
著者名 Ishii, Chihiro
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Ichise, Takahiro
著者名 Saito, Keisuke
著者名 Watanabe, Yukiko
著者名 Ogasawara, Kohei
著者名 Torimoto, Ryota
著者名 Kobayashi, Atsushi
e-Rad_Researcher 90261338 著者名 Kimura, Takashi
著者名 Nakamura, Yukiko
e-Rad_Researcher 80535328 著者名 Yamagishi, Junya
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Duck
	Lead (pb) exposure
	Toxicological effects
	Waterfowl
発行日	2022-09-01
出版者	Elsevier
収録物名	Environmental pollution
巻(号)	308
ページ	119580
抄録	Among wild birds, lead (Pb) exposure caused by ingestion of ammunition is a worldwide problem. We aimed to reveal the behavior and toxic effect of Pb caused by ingesting Pb shots in waterfowl. Four male, eight-week old Muscovy ducks (Cairina moschata) were given three Pb shots (approximately 240 mg in total) orally and then fed for 29 days after exposure, simulating a low-dose Pb exposure in wild waterfowl. During the breeding period, blood samples were collected 10 times, and fecal samples every day. Additionally, 22 fresh tissue and 6 bone samples were obtained from each duck through the dissection. Although there were no gross abnormalities, the maximum blood Pb concentration of each duck ranged from 0.6 to 3.7 mg/L, reaching a threshold concentration indicative of clinical symptoms (>0.5 mg/L). delta-aminolevulinic acid dehydratase declined one day after exposure and remained low throughout the feeding period. Hematocrit also tended to decrease, indicating signs of anemia. The highest Pb accumulation was observed in the bones, followed by the kidneys, intestinal tracts, and liver. High Pb accumulation in the bones, which are known to have a long Pb half-life, suggested that Pb would remain in the body and possibly affect bird health beyond 28 days after exposure. Gene expression analysis showed a significant increase in the expression of the toll-like receptor-3 gene, which is involved in virus discrimination in the liver, suggesting a disruption of the immune system. Microbiota analyses showed a correlation between the blood Pb concentration and the abundances of Lachnospiraceae and Ruminococcaceae, suggesting that Pb affects lipid metabolism. These results provide fundamental data on Pb exposure in wild birds and a new perspective on the damage such exposure causes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2022>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0269-7491
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envpol.2022.119580