α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation

Terada, Naofumi; Nagase, Tomoaki; Kayooka, Hiromi; Adachi, Yusuke; Kato, Eisuke

α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation

Terada, Naofumi; Nagase, Tomoaki; Kayooka, Hiromi et al.

Bioscience biotechnology and biochemistry, 2023, 88(2), 189-195

Permalink : https://hdl.handle.net/2115/93249

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/93249
タイトル	α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation
著者	Terada, Naofumi ; Nagase, Tomoaki ; Kayooka, Hiromi ; Adachi, Yusuke ; Kato, Eisuke
著者名 Terada, Naofumi
著者名 Nagase, Tomoaki
著者名 Kayooka, Hiromi
著者名 Adachi, Yusuke
e-Rad_Researcher 40466446 著者名 Kato, Eisuke
言語	英語
キーワード	rice bran
	tocotrienol
	Leydig cell
	testosterone
	late-onset hypogonadism
発行日	2023-10-25
出版者	Oxford University Press
収録物名	Bioscience biotechnology and biochemistry
巻(号)	88(2)
ページ	189-195
抄録	Rice is a staple food in the Asian region and one of the world's major energy sources. Testosterone is a steroid hormone that maintains physical, sexual, and cognitive ability, and its decline causes health problems like late-onset hypogonadism. Evaluation of various grain extracts showed rice bran to stimulate testosterone secretion from Leydig model cells. alpha-Tocotrienol was found as a bioactive compound in rice bran, and mechanistic analysis showed the stimulation of steroid hormone synthesis through enhanced gene expression of steroidogenic acute regulatory protein as well as inducing mitochondrial localization of the protein. Preliminary study showed an increasing trend in serum testosterone levels in mice by oral intake of alpha-tocotrienol. These results suggest that alpha-tocotrienol intake may be effective in preventing symptoms caused by low testosterone levels. Graphical Abstract Tocotrienol, a constituent of rice bran, was discovered as a bioactive compound that promotes steroidogenesis in Leydig cells.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Naofumi Terada, Tomoaki Nagase, Hiromi Kayooka, Yusuke Adachi, Eisuke Kato, α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation, Bioscience, Biotechnology, and Biochemistry, Volume 88, Issue 2, February 2024, Pages 189–195, is available online at: https://doi.org/10.1093/bbb/zbad153.
PISSN	0916-8451
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/bbb/zbad153