Treatment outcomes of the patient with sinonasal mucosal melanoma : the role of endoscopic resection and postoperative radiotherapy

Tsushima, Nayuta; Kano, Satoshi; Yasuda, Koichi; Suzuki, Takayoshi; Hamada, Seijiro; Nakamaru, Yuji; Suzuki, Masanobu; Uchinami, Yusuke; Aoyama, Hidefumi; Homma, Akihiro

Treatment outcomes of the patient with sinonasal mucosal melanoma : the role of endoscopic resection and postoperative radiotherapy

Tsushima, Nayuta; Kano, Satoshi; Yasuda, Koichi et al.

International journal of clinical oncology, 2023, 28(9), 1218-1226

Permalink : https://hdl.handle.net/2115/93384

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アクセス権	open access
URI	https://hdl.handle.net/2115/93384
タイトル	Treatment outcomes of the patient with sinonasal mucosal melanoma : the role of endoscopic resection and postoperative radiotherapy
著者	Tsushima, Nayuta ; Kano, Satoshi ; Yasuda, Koichi ; Suzuki, Takayoshi ; Hamada, Seijiro ; Nakamaru, Yuji ; Suzuki, Masanobu ; Uchinami, Yusuke ; Aoyama, Hidefumi ; Homma, Akihiro
e-Rad_Researcher 50547643 著者名 Tsushima, Nayuta
著者名 Kano, Satoshi
著者名 Yasuda, Koichi
著者名 Suzuki, Takayoshi
著者名 Hamada, Seijiro
著者名 Nakamaru, Yuji
著者名 Suzuki, Masanobu
著者名 Uchinami, Yusuke
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
言語	英語
キーワード	Sinonasal mucosal melanoma
	Endoscopic resection
	Postoperative radiotherapy
	Adjuvant therapy
	Distant metastasis
発行日	2023-09-01
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	28(9)
ページ	1218-1226
抄録	BackgroundThe standard of care for sinonasal mucosal melanoma is surgery and postoperative radiotherapy (PORT). Our treatment strategy comprises endoscopic resection and PORT. We performed combined endoscopic and open resection or applied an external approach alone when sufficient resection was difficult to achieve endoscopically. The objective of this study was to evaluate the validity of our treatment strategy.MethodsWe assessed 30 patients with sinonasal mucosal melanoma who underwent definitive therapy between January 2002 and April 2021, and conducted a retrospective analysis. The median follow-up period was 2.2 years. The primary endpoint was overall survival. The Kaplan-Meier method was used for the calculation of survival rates, the cumulative incidence of distant metastasis, and local recurrence.ResultsTwenty-eight patients underwent surgery. The other two patients were treated by definitive proton beam therapy. Twenty-one of 28 (75%) patients underwent resection by endoscopic approach alone. Postoperative radiotherapy was performed for all 28 patients who underwent surgery. Twenty-one patients (70%) experienced recurrence during the observation period. Overall, distant metastasis was observed in 19 patients. Twelve patients died during the observation period, with 10 of the 12 patients (83%) dying of distant metastasis. The overall survival rate at 2 and 5 years was 70% and 46%, respectively. The cumulative incidence rate of distant metastasis at 2 years was 63%, while the 2-year cumulative incidence rate of local recurrence was 6.7%.ConclusionThe local disease was controlled by our treatment strategy. To improve treatment outcomes, control of the distant metastasis is needed.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10147-023-02368-0
PISSN	1341-9625
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-023-02368-0