Early gene expression profiles of anabolic and catabolic molecules in murine bone after a single PTH injection

Yamamoto, Tomomaya; Maruoka, Haruhi; Hongo, Hiromi; Yoshino, Hirona; Haraguchi-Kitakamae, Mai; Liu, Xuanyu; Yao, Qi; Li, Minqi; Amizuka, Norio; Hasegawa, Tomoka

Early gene expression profiles of anabolic and catabolic molecules in murine bone after a single PTH injection

Yamamoto, Tomomaya; Maruoka, Haruhi; Hongo, Hiromi et al.

Journal of oral biosciences, 2023, 65(4), 395-400

Permalink : https://hdl.handle.net/2115/93557

このアイテムのアクセス数:167件（2026-08-13 20:42 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/93557
タイトル	Early gene expression profiles of anabolic and catabolic molecules in murine bone after a single PTH injection
著者	Yamamoto, Tomomaya ; Maruoka, Haruhi ; Hongo, Hiromi ; Yoshino, Hirona ; Haraguchi-Kitakamae, Mai ; Liu, Xuanyu ; Yao, Qi ; Li, Minqi ; Amizuka, Norio ; Hasegawa, Tomoka
e-Rad_Researcher 50928299 著者名 Yamamoto, Tomomaya
e-Rad_Researcher 40962577 著者名 Maruoka, Haruhi
e-Rad_Researcher 00778970 著者名 Hongo, Hiromi
著者名 Yoshino, Hirona
著者名 Haraguchi-Kitakamae, Mai
著者名 Liu, Xuanyu
著者名 Yao, Qi
e-Rad_Researcher 60447612 著者名 Li, Minqi
e-Rad_Researcher 30242431 著者名 Amizuka, Norio
e-Rad_Researcher 50739349 著者名 Hasegawa, Tomoka
言語	英語
キーワード	Parathyroid hormone (PTH)
	Anabolic effect
	Alkaline phosphatase
	Runx2
	Rankl
発行日	2023-12
出版者	Elsevier
収録物名	Journal of oral biosciences
巻(号)	65(4)
ページ	395-400
抄録	The current study examined the gene expression profiles of anabolic and catabolic molecules after a single parathyroid hormone (PTH) injection in mice. No significant changes were observed in alkaline phosphatase area/tissue volume, tartrate-resistant acid phosphatase-positive osteoclasts, or static bone histomorphometry parameters. However, a sudden and significant decrease in Runx2 expression occurred at 1.5 h post-injection followed by immediate elevation, while sclerostin level was initially downregulated but gradually recovered. Meanwhile, Rankl expression initially increased and then returned to baseline. The prolonged elevation of anabolic molecules and transient increase in catabolic molecules may contribute to the anabolic effect of PTH treatment.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1349-0079
NCID	AA11896386
関連情報	PMID 37595743
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.job.2023.08.003