open access

https://hdl.handle.net/2115/93577

What is the switch for coupling transcription and splicing? RNA Polymerase II C-terminal domain phosphorylation, phase separation and beyond.

英語

2019-11-03

Wiley interdisciplinary reviews. RNA

11(1)

e1574

Phosphorylation of the RNA polymerase II C-terminal domain (Pol II CTD) has important roles in the kinetic coupling of splicing with transcription, which is essential for many genes to maintain correct splicing patterns. However, because of the extensively repeated low complexity sequences of Pol II CTD, it was unclear how phosphorylation-dependent molecular interactions were able to provide sufficient specificity to spatiotemporally partition various cotranscriptional events. Here we try to view the molecular mechanisms governing cotranscriptional splicing from the role of phase separation based on recent studies showing the ability of Pol II CTD to form droplets.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1574, which has been published in final form at 10.1002/wrna.1574. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

1757-7012