Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis

Sun, Kai; Huang, Chung-Yang Dennis; Sawamura, Masaya et al.

Synlett, 2023, 34(18), 2210-2214

Permalink : https://hdl.handle.net/2115/93707

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アクセス権	open access
URI	https://hdl.handle.net/2115/93707
タイトル	Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis
著者	Sun, Kai ; Huang, Chung-Yang Dennis ; Sawamura, Masaya ; Shimizu, Yohei
著者名 Sun, Kai
著者名 Huang, Chung-Yang Dennis
e-Rad_Researcher 40202105 著者名 Sawamura, Masaya
e-Rad_Researcher 60609816 著者名 Shimizu, Yohei
言語	英語
キーワード	carboxylic acid
	boron catalyst
	trifluoromethylthiolation
	data science
	drug modification
	fluorine compounds
発行日	2023-11
出版者	Georg Thieme Verlag
収録物名	Synlett
巻(号)	34(18)
ページ	2210-2214
抄録	A boron-catalyzed direct a-trifluoromethylthiolation of carboxylic acids was developed. Catalytically generated boron enediolates reacts with electrophilic SCF3 reagent, N-SCF3-phthalimide, to provide a-SCF3 carboxylic acids without the need of substrate pre-activation. The method is applicable to direct modification of bioactive carboxylic acids. Data science analyses provided suitable models for substrate clas-sification as well as yield prediction.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0936-5214
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1055/a-2071-4465