Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol

Matsuya, Yusuke; Sato, Tatsuhiko; Kusumoto, Tamon; Yachi, Yoshie; Seino, Ryosuke; Miwa, Misako; Ishikawa, Masayori; Matsuyama, Shigeo; Fukunaga, Hisanori

Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol

Matsuya, Yusuke; Sato, Tatsuhiko; Kusumoto, Tamon et al.

Scientific Reports, 2024, 14(1), 16696

Permalink : https://hdl.handle.net/2115/93860

このアイテムのアクセス数:211件（2026-08-19 18:41 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/93860
タイトル	Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol
著者	Matsuya, Yusuke ; Sato, Tatsuhiko ; Kusumoto, Tamon ; Yachi, Yoshie ; Seino, Ryosuke ; Miwa, Misako ; Ishikawa, Masayori ; Matsuyama, Shigeo ; Fukunaga, Hisanori
e-Rad_Researcher 20826929 著者名 Matsuya, Yusuke
e-Rad_Researcher 30354707 著者名 Sato, Tatsuhiko
e-Rad_Researcher 90825499 著者名 Kusumoto, Tamon
著者名 Yachi, Yoshie
e-Rad_Researcher 61006194 著者名 Seino, Ryosuke
著者名 Miwa, Misako
e-Rad_Researcher 80314772 著者名 Ishikawa, Masayori
著者名 Matsuyama, Shigeo
e-Rad_Researcher 50781267 著者名 Fukunaga, Hisanori
言語	英語
キーワード	BNCT
	BPA
	Cell cycle
	CR-39 detector
	Heavy ions
	PVA
発行日	2024-07-19
出版者	Nature Publishing
収録物名	Scientific Reports
巻(号)	14(1)
ページ	16696
抄録	Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-l-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報	PMID 39030350
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-024-67041-6