In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi

Muramatsu, Daisuke; Uchiyama, Hirofumi; Kida, Hiroshi; Iwai, Atsushi

In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi

Muramatsu, Daisuke; Uchiyama, Hirofumi; Kida, Hiroshi et al.

Heliyon, 2020, 6(12), e05505

Permalink : https://hdl.handle.net/2115/93897

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アクセス権	open access
URI	https://hdl.handle.net/2115/93897
タイトル	In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi
著者	Muramatsu, Daisuke ; Uchiyama, Hirofumi ; Kida, Hiroshi ; Iwai, Atsushi
著者名 Muramatsu, Daisuke
著者名 Uchiyama, Hirofumi
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
著者名 Iwai, Atsushi
言語	英語
キーワード	Japanese larch
	Larix kaempferi
	Taxifolin
	Inflammation
	Lipid accumulation
	Adipocytes
	Macrophages
	Food science
	Bioactive compound
	Biochemical characterization of food
	Plant products
	Cell culture
	Cytotoxicity
	Polyphenol
	Flavonoid
	Alternative medicine
発行日	2020-12
出版者	Elsevier
収録物名	Heliyon
巻(号)	6(12)
ページ	e05505
抄録	The Japanese larch, (Larix kaempferi) is known to contain abundant taxifolin (dihydroquercetin) in its xylem. In this study, to assess the bioactivities of taxifolin rich methanol extract of L. kaempferi (LK-ME), anti-inflammatory effect, and the anti-lipid accumulation effect of LK-ME were investigated. The results showed that nitric oxide (NO) and reactive oxygen species (ROS) were reduced after treatment with LK-ME, and that lipid accumulation in adipocyte differentiated 3T3-L1 cells was inhibited after the cells were grown in medium containing LK-ME. Taxifolin, the major compound contained in LK-ME, and its related compounds, quercetin and luteolin also exhibited similar effects with LK-ME. The LK-ME exhibits relatively strong anti-inflammatory and anti-lipid accumulation activities compared with that of similar amounts of taxifolin contained in LK-ME, suggesting that other minor compounds contained in LK-ME is involved in the effects. These results indicate the potential of taxifolin-rich L. kaempferi extract for use as a supplement to prevent excess inflammation and obesity.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	2405-8440
関連情報	PMID 33336091
関連情報	CRID 1360298761855618432
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.heliyon.2020.e05505