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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/93906
タイトル	Asymmetric Hydrogenation of α-Alkyl-Substituted β-Keto Esters and Amides through Dynamic Kinetic Resolution
著者	Yurino, Taiga ; Nishihara, Ryo ; Yasuda, Toshihisa ; Yang, Shuangli ; Utsumi, Noriyuki ; Katayama, Takeaki ; Arai, Noriyoshi ; Ohkuma, Takeshi
e-Rad_Researcher 20771504 著者名 Yurino, Taiga
著者名 Nishihara, Ryo
著者名 Yasuda, Toshihisa
著者名 Yang, Shuangli
著者名 Utsumi, Noriyuki
著者名 Katayama, Takeaki
e-Rad_Researcher 80282721 著者名 Arai, Noriyoshi
e-Rad_Researcher 50201968 著者名 Ohkuma, Takeshi
言語	英語
発行日	2024-04-12
出版者	American Chemical Society
収録物名	Organic letters
巻(号)	26(14)
ページ	2872-2876
抄録	Asymmetric hydrogenation of alpha-alkyl-substituted beta-keto esters and amides with the DIPSkewphos/3-AMIQ-Ru(II) catalyst system through dynamic kinetic resolution was examined. A series of beta-keto esters and amides with a simple or functionalized alpha-alkyl group were applicable to this reaction, affording the alpha-substituted beta-hydroxy esters and amides in >= 99% ee (anti/syn >= 99:1) in many cases. The 5 g scale reaction was readily achieved. The mode of enantio- and diastereoselection in the transition state model was proposed.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © 2024　American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-Y3KFDPWMXN7XQ3FGW8I6.
PISSN	1523-7060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.orglett.3c04036

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