Dynamic morphometric changes in the mandibular osteocytic lacunae of ovariectomized rats in response to teriparatide, as revealed by three-dimensional fluorescence analyses: Possible involvement of osteocytic perilacunar remodeling

Nakanishi-Kimura, Atsuko; Takakura, Aya; Hoshi-Numahata, Marie; Watanabe, Haruhisa; Nishiura, Mai; Sato, Yoshiaki; Takao-Kawabata, Ryoko; Iimura, Tadahiro

Dynamic morphometric changes in the mandibular osteocytic lacunae of ovariectomized rats in response to teriparatide, as revealed by three-dimensional fluorescence analyses: Possible involvement of osteocytic perilacunar remodeling

Nakanishi-Kimura, Atsuko; Takakura, Aya; Hoshi-Numahata, Marie et al.

Journal of oral biosciences, 2024, 66(1), 49-60

Permalink : https://hdl.handle.net/2115/93910

このアイテムのアクセス数:177件（2026-08-15 08:17 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/93910
タイトル	Dynamic morphometric changes in the mandibular osteocytic lacunae of ovariectomized rats in response to teriparatide, as revealed by three-dimensional fluorescence analyses: Possible involvement of osteocytic perilacunar remodeling
著者	Nakanishi-Kimura, Atsuko ; Takakura, Aya ; Hoshi-Numahata, Marie ; Watanabe, Haruhisa ; Nishiura, Mai ; Sato, Yoshiaki ; Takao-Kawabata, Ryoko ; Iimura, Tadahiro
著者名 Nakanishi-Kimura, Atsuko
著者名 Takakura, Aya
e-Rad_Researcher 71001369 著者名 Hoshi-Numahata, Marie
著者名 Watanabe, Haruhisa
著者名 Nishiura, Mai
e-Rad_Researcher 00250465 著者名 Sato, Yoshiaki
著者名 Takao-Kawabata, Ryoko
e-Rad_Researcher 20282775 著者名 Iimura, Tadahiro
言語	英語
キーワード	Teriparatide
	Craniofacial bone
	Osteocytic lacunae
	Bone remodeling
	Imaging
発行日	2024-03
出版者	Elsevier
収録物名	Journal of oral biosciences
巻(号)	66(1)
ページ	49-60
抄録	Objectives: Teriparatide [TPTD; human parathyroid hormone (hPTH1-34)] is an anti-osteoporotic drug with bone anabolic effects. Clinical and preclinical studies have indicated that TPTD has value in oral and maxillofacial bone therapies, including jawbone regeneration, periodontal tissue repair, and the treatment of medicationrelated osteonecrosis of the jaw. However, it is unclear whether the craniofacial bones respond to TPTD similarly to the axial and appendicular bones. Recent studies showed that TPTD acts on both osteocytes and osteoblasts. This study aimed to characterize distinct craniofacial bone sites, with a focus on morphometric changes in osteocytic lacunae in ovariectomized rats receiving TPTD. Methods: Conventional bone histomorphometric analyses of mandibular and parietal bone sections were conducted. High-resolution confocal imaging-based three-dimensional fluorescence morphometric analyses of osteocytic lacunae in distinct mandibular and parietal bone sites were conducted. Results: We observed dynamic changes in the morphometric characteristics of osteocytic lacunae specifically in alveolar and other mandibular bone sites upon TPTD administration. Conclusions: These findings suggest that osteocytes in mandibular bone (specifically, alveolar bone) have unique functional characteristics of osteocytic perilacunar remodeling.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1349-0079
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.job.2023.11.010