Impact of cancer on the prevalence, management, and outcome of patients with chronic thromboembolic pulmonary hypertension

Nakamura, Junichi; Tsujino, Ichizo; Shima, Hideki; Nakaya, Toshitaka; Sugimoto, Ayako; Sato, Takahiro; Watanabe, Taku; Ohira, Hiroshi; Suzuki, Masaru; Yokota, Isao; Konno, Satoshi

Impact of cancer on the prevalence, management, and outcome of patients with chronic thromboembolic pulmonary hypertension

Nakamura, Junichi; Tsujino, Ichizo; Shima, Hideki et al.

Journal of thrombosis and thrombolysis, 2023, 56(4), 588-593

Permalink : https://hdl.handle.net/2115/93911

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アクセス権	open access
URI	https://hdl.handle.net/2115/93911
タイトル	Impact of cancer on the prevalence, management, and outcome of patients with chronic thromboembolic pulmonary hypertension
著者	Nakamura, Junichi ; Tsujino, Ichizo ; Shima, Hideki ; Nakaya, Toshitaka ; Sugimoto, Ayako ; Sato, Takahiro ; Watanabe, Taku ; Ohira, Hiroshi ; Suzuki, Masaru ; Yokota, Isao ; Konno, Satoshi
著者名 Nakamura, Junichi
e-Rad_Researcher 00344507 著者名 Tsujino, Ichizo
著者名 Shima, Hideki
著者名 Nakaya, Toshitaka
著者名 Sugimoto, Ayako
著者名 Sato, Takahiro
著者名 Watanabe, Taku
著者名 Ohira, Hiroshi
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
e-Rad_Researcher 20761414 著者名 Yokota, Isao
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Survival
	Cause of death
	Breast cancer
	Gastrointestinal tract
発行日	2023-11-01
出版者	Springer
収録物名	Journal of thrombosis and thrombolysis
巻(号)	56(4)
ページ	588-593
抄録	Introduction Chronic thromboembolic pulmonary hypertension (CTEPH) results from unresolved thrombotic obstruction of the pulmonary vasculature. Cancer is a known risk factor for CTEPH. This study aimed to determine the impact of cancer on the prevalence, management, and outcomes of patients with CTEPH. Materials and methods In this retrospective study involving 99 patients sequentially diagnosed with CTEPH in our hospital, the prevalence of 10 comorbid conditions including a past history of cancer at the time of CTEPH diagnosis were calculated. Results Among the 99 patients, 17 (17%) had a history of cancer. Breast cancer (n = 6) was the most common cancer type, followed by gastrointestinal cancer (n = 3), uterine cancer (n = 2), and malignant lymphoma (n = 2). Between patients with and without cancer, there were no differences in the demographics, severity of CTEPH, and management; however, the 5-year survival rate was lower for patients with cancer (65%) than for those without (89%). In addition, patients with cancer had significantly worse survival than those without (p = 0.03 by log-rank test). During follow-up, nine patients developed cancer after the diagnosis of CTEPH. Among the 99 patients, 13 died during follow-up, 6 (46%) of whom died of cancer. Conclusions 17% of our patients with CETPH were diagnosed with cancer, with breast and gastrointestinal tract cancers being the most common. Cancer comorbidity was associated with a poor prognosis and contributed to death in 46% of deceased patients. The impact of cancer on CTEPH should be further evaluated in the future.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11239-023-02868-w
PISSN	0929-5305
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11239-023-02868-w