Asymmetric Cyanation of α-Ketimino Ester Derivatives with Chiral Ru-Li Combined Catalysts

Yurino, Taiga; Wu, Zhen; Suzuki, Kazuaki et al.

Organic letters, 2024, 26(4), 900-905

Permalink : https://hdl.handle.net/2115/93944

このアイテムのアクセス数:138件（2026-10-12 03:48 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
Org. Lett. 26(4)900 pdf 653 KB 192

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/93944
タイトル
Asymmetric Cyanation of α-Ketimino Ester Derivatives with Chiral Ru-Li Combined Catalysts
著者
Yurino, Taiga ; Wu, Zhen ; Suzuki, Kazuaki ; Nitta, Rino ; Sakaguchi, Yusuke ; Ohkuma, Takeshi
e-Rad_Researcher
20771504
著者名
Yurino, Taiga
著者名
Wu, Zhen
著者名
Suzuki, Kazuaki
著者名
Nitta, Rino
著者名
Sakaguchi, Yusuke
e-Rad_Researcher
50201968
著者名
Ohkuma, Takeshi
言語
英語
発行日
2024-02-02
出版者
American Chemical Society
収録物名
Organic letters
巻(号)
26(4)
ページ
900-905
抄録
Asymmetric cyanation of alpha-ketimino esters catalyzed by combined systems of amino acid/BINAP derivative/Ru-(II) complexes and lithium compounds was examined. The use of an appropriate combination of amino acid and BINAP ligands achieved high enantioselectivity for a variety of alpha-alkynyl (Val/XylBINAP/Ru), alpha-alkenyl (Val/TolBINAP/Ru), and alpha-aryl imino esters (Val/XylBINAP/Ru) as well as an isatin-derived cyclic imino amide (t-Leu/BINAP/Ru) to afford the alpha-cyano-alpha-amino esters and the amide with an alpha-nitrogen-substituted quaternary chiral center with up to 98% ee.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-CXKPUWJAVRXGUCEGVBIK.
PISSN
1523-7060
関連情報
PMID
38251826
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1021/acs.orglett.3c04175