Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension

Nagai, Yui; Murayama, Michito; Kaga, Sanae et al.

International journal of cardiovascular imaging, 2024, 40(5), 1123-1134

Permalink : https://hdl.handle.net/2115/94304

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アクセス権
open access
URI
https://hdl.handle.net/2115/94304
タイトル
Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension
著者
Nagai, Yui ; Murayama, Michito ; Kaga, Sanae ; Shima, Hideki ; Tsuneta, Satonori ; Yokoyama, Shinobu ; Nishino, Hisao ; Goto, Mana ; Suzuki, Yukino ; Yanagi, Yusuke ; Ishizaka, Suguru ; Iwano, Hiroyuki ; Nakamura, Junichi ; Sato, Takahiro ; Tsujino, Ichizo
著者名
Nagai, Yui
e-Rad_Researcher
10964497
著者名
Murayama, Michito
e-Rad_Researcher
60630978
著者名
Kaga, Sanae
著者名
Shima, Hideki
著者名
Tsuneta, Satonori
著者名
Yokoyama, Shinobu
著者名
Nishino, Hisao
著者名
Goto, Mana
著者名
Suzuki, Yukino
著者名
Yanagi, Yusuke
著者名
Ishizaka, Suguru
e-Rad_Researcher
50622354
著者名
Iwano, Hiroyuki
著者名
Nakamura, Junichi
著者名
Sato, Takahiro
e-Rad_Researcher
00344507
著者名
Tsujino, Ichizo
言語
英語
キーワード
Echocardiography
Pulmonary hypertension
Diastolic function
Right ventricular diastolic stiffness
Right ventricular hemodynamic evaluation
Pulmonary regurgitation
発行日
2024-03-27
出版者
Springer
収録物名
International journal of cardiovascular imaging
巻(号)
40(5)
ページ
1123-1134
抄録
Right ventricular (RV) diastolic stiffness is an independent predictor of survival and is strongly associated with disease severity in patients with precapillary pulmonary hypertension (PH). Therefore, a fully validated echocardiographic method for assessing RV diastolic stiffness needs to be established. This study aimed to compare echocardiography-derived RV diastolic stiffness and invasively measured pressure-volume loop-derived RV diastolic stiffness in patients with precapillary PH. We studied 50 consecutive patients with suspected or confirmed precapillary PH who underwent cardiac catheterization, magnetic resonance imaging, and echocardiography within a 1-week interval. Single-beat RV pressure-volume analysis was performed to determine the gold standard for RV diastolic stiffness. Elevated RV end-diastolic pressure (RVEDP) was defined as RVEDP >= 8 mmHg. Using continuous-wave Doppler and M-mode echocardiography, an echocardiographic index of RV diastolic stiffness was calculated as the ratio of the atrial-systolic descent of the pulmonary artery-RV pressure gradient derived from pulmonary regurgitant velocity (PRPGD(AC)) to the tricuspid annular plane movement during atrial contraction (TAPM(AC)). PRPGD(AC)/TAPM(AC) showed significant correlation with beta (r = 0.54, p < 0.001) and RVEDP (r = 0.61, p < 0.001). A cut-off value of 0.74 mmHg/mm for PRPGD(AC)/TAPM(AC) showed 83% sensitivity and 93% specificity for identifying elevated RVEDP. Multivariate analyses indicated that PRPGD(AC)/TAPM(AC) was independently associated with disease severity in patients with precapillary PH, including substantial PH symptoms, stroke volume index, right atrial size, and pressure. PRPGD(AC)/TAPM(AC), based on pulmonary regurgitation velocity waveform analysis, is useful for the noninvasive assessment of RV diastolic stiffness and is associated with prognostic risk factors in precapillary PH.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10554-024-03083-1
PISSN
1569-5794
NCID
AA11582413
関連情報
PMID
38536607
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s10554-024-03083-1