Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use : a preliminary single-group interventional study

Shingu, Yasushige; Yokota, Isao; Shichinohe, Toshiaki; Murakami, Soichi; Ebihara, Yuma; Kurashima, Yo; Hirano, Satoshi; Wakasa, Satoru

Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use : a preliminary single-group interventional study

Shingu, Yasushige; Yokota, Isao; Shichinohe, Toshiaki et al.

Surgery today, 2024, 54, 892-898

Permalink : https://hdl.handle.net/2115/94665

このアイテムのアクセス数:280件（2026-10-10 18:05 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
HUSCAP_Eso_Carnitine_Surg Today	pdf	472 KB	182

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/94665
タイトル	Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use : a preliminary single-group interventional study
著者	Shingu, Yasushige ; Yokota, Isao ; Shichinohe, Toshiaki ; Murakami, Soichi ; Ebihara, Yuma ; Kurashima, Yo ; Hirano, Satoshi ; Wakasa, Satoru
著者名 Shingu, Yasushige
e-Rad_Researcher 20761414 著者名 Yokota, Isao
e-Rad_Researcher 70374353 著者名 Shichinohe, Toshiaki
e-Rad_Researcher 80706573 著者名 Murakami, Soichi
e-Rad_Researcher 50632981 著者名 Ebihara, Yuma
e-Rad_Researcher 40374350 著者名 Kurashima, Yo
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
e-Rad_Researcher 10374365 著者名 Wakasa, Satoru
言語	英語
キーワード	Postoperative atrial fibrillation
	Esophagus
	Cardiovascular
発行日	2024-02-23
出版者	SpringerNature
収録物名	Surgery today
巻(号)	54
ページ	892-898
抄録	Purpose We aimed to investigate the POAF rate and blood FABP4 levels after perioperative L-carnitine administration in patients with esophageal cancer. Methods L-carnitine (3 g in three divided doses) was administered to 15 patients 2 days before and 3 days after surgery. POAF during the study period and blood FABP4 levels (ELISA) before and after L-carnitine administration were evaluated. Accurate 95% confidence intervals (CI) for POAF incidence and changes in blood FABP4 levels were calculated. The preoperative predicted POAF rate was calculated using an application for esophageal cancer. The correlation between FABP4 levels and the predicted POAF rate was analyzed using Pearson’s coefficient (r). Results Thirteen patients completed this study. The predicted POAF rate was 24% (17%, 34%) (median; interquartile range). The actual incidence of POAF was 7.7% (95% CI: 0.2–36%). Blood FABP4 levels changed from 10.3 to 7.0 ng/mL; the average change was − 3.3 (95% CI: − 6.6 to − 0.1). A positive correlation was found between preoperative FABP4 levels and the predicted POAF rates (r = 0.564). Conclusions The POAF rate after esophageal surgery was 7.7% for L-carnitine. L-carnitine may reduce blood FABP4 levels. This preliminary study will contribute to the planning of sample sizes in future randomized trials.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00595-024-02802-4
PISSN	0941-1291
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00595-024-02802-4