Fabrication of Ciprofloxacin-Immobilized Calcium Phosphate Particles for Dental Drug Delivery

Pal, Aniruddha; Oyane, Ayako; Inose, Tomoya; Nakamura, Maki; Nishida, Erika; Miyaji, Hirofumi

Fabrication of Ciprofloxacin-Immobilized Calcium Phosphate Particles for Dental Drug Delivery

Pal, Aniruddha; Oyane, Ayako; Inose, Tomoya et al.

Materials, 2024, 17(9), 2035

Permalink : https://hdl.handle.net/2115/94720

このアイテムのアクセス数:160件（2026-07-12 06:19 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/ma17092035			52

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/94720
タイトル	Fabrication of Ciprofloxacin-Immobilized Calcium Phosphate Particles for Dental Drug Delivery
著者	Pal, Aniruddha ; Oyane, Ayako ; Inose, Tomoya ; Nakamura, Maki ; Nishida, Erika ; Miyaji, Hirofumi
著者名 Pal, Aniruddha
e-Rad_Researcher 50356672 著者名 Oyane, Ayako
e-Rad_Researcher 10930448 著者名 Inose, Tomoya
e-Rad_Researcher 00568925 著者名 Nakamura, Maki
e-Rad_Researcher 50779882 著者名 Nishida, Erika
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
言語	英語
キーワード	coprecipitation
	antibacterial activity
	biofilm
	carrier
	ciprofloxacin
発行日	2024-04-26
出版者	MDPI
収録物名	Materials
巻(号)	17(9)
ページ	2035
抄録	Calcium phosphate (CaP) particles immobilizing antibacterial agents have the potential to be used as dental disinfectants. In this study, we fabricated CaP particles with immobilized ciprofloxacin (CF), a commonly prescribed antibacterial agent, via a coprecipitation process using a supersaturated CaP solution. As the aging time in the coprecipitation process increased from 2 to 24 h, the CaP phase in the resulting particles transformed from amorphous to low-crystalline hydroxyapatite, and their Ca/P elemental ratio, yield, and CF content increased. Despite the higher CF content, the particles aged for 24 h displayed a slower release of CF in a physiological salt solution, most likely owing to their crystallized matrix (less soluble hydroxyapatite), than those aged for 2 h, whose matrix was amorphous CaP. Both particles exhibited antibacterial and antibiofilm activities along with an acid-neutralizing effect against the major oral bacteria, Streptococcus mutans, Porphyromonas gingivalis, and Actinomyces naeslundii, in a dose-dependent manner, although their dose–response relationship was slightly different. The aging time in the coprecipitation process was identified as a governing factor affecting the physicochemical properties of the resulting CF-immobilized CaP particles and their functionality as a dental disinfectant.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1996-1944
関連情報	PMID 38730839
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ma17092035