Subtle radiographic progression at 6 months can be detected using automated quantitative software in rheumatoid arthritis while receiving tocilizumab

Okino, Taichi; Ou, Yafei; Ikebe, Masayuki; Furusaki, Akira; Sagawa, Akira; Kato, Masaru; Atsumi, Tatsuya; Sutherland, Kenneth; Kamishima, Tamotsu

Subtle radiographic progression at 6 months can be detected using automated quantitative software in rheumatoid arthritis while receiving tocilizumab

Okino, Taichi; Ou, Yafei; Ikebe, Masayuki et al.

Modern rheumatology, 2024, 35(1), 72-78

Permalink : https://hdl.handle.net/2115/94856

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アクセス権	open access
URI	https://hdl.handle.net/2115/94856
タイトル	Subtle radiographic progression at 6 months can be detected using automated quantitative software in rheumatoid arthritis while receiving tocilizumab
著者	Okino, Taichi ; Ou, Yafei ; Ikebe, Masayuki ; Furusaki, Akira ; Sagawa, Akira ; Kato, Masaru ; Atsumi, Tatsuya ; Sutherland, Kenneth ; Kamishima, Tamotsu
著者名 Okino, Taichi
著者名 Ou, Yafei
e-Rad_Researcher 20374613 著者名 Ikebe, Masayuki
著者名 Furusaki, Akira
著者名 Sagawa, Akira
著者名 Kato, Masaru
著者名 Atsumi, Tatsuya
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth
e-Rad_Researcher 10399868 著者名 Kamishima, Tamotsu
言語	英語
キーワード	Finger joint
	joint space narrowing
	radiography
	rheumatoid arthritis
	software
発行日	2024-05-16
出版者	Oxford University Press
収録物名	Modern rheumatology
巻(号)	35(1)
ページ	72-78
抄録	Objectives: We investigated whether our in-house software equipped with partial image phase-only correlation (PIPOC) can detect subtle radiographic joint space narrowing (JSN) progression at 6 months and predict JSN progression in rheumatoid arthritis (RA) patients receiving Tocilizumab. Methods: The study included 39 RA patients who were treated with Tocilizumab. Radiological progression of the finger joints was evaluated according to the Genant-modified Sharp score (GSS) at 0, 6, and 12 months. Results: The success rate of the software for joint space width (JSW) measurement was 96.8% (449/464). The 0-12-month JSW change by the software was significantly greater in joints with the 0-6-month PIPOC (+) group than the 0-6-month PIPOC (-) group (P < 0.001). The 0-12-month JSW change by the software was 0-12 month GSS (+) than with 0-12 month GSS (-) (P = 0.02). Here, '(+)' indicates the JSN progression during the follow-up period. Linear regression tests showed significant correlations between the 0-6 month and the 0-12 month PIPOC in the left second and third metacarpophalangeal joints (R-2 = 0.554 and 0.420, respectively). Conclusions: Our in-house software equipped with PIPOC could predict subsequent JSN progression with only short-term observations.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Modern rheumatology following peer review. The version of record Volume 35, Issue 1, January 2025, Pages 72–78, is available online at: https://doi.org/10.1093/mr/roae047
PISSN	1439-7595
NCID	AA1157187X
関連情報	PMID 38753311
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/mr/roae047