Spatiotemporal regulation of CENP-E-guided chromosomes using a fast-relaxing arylazopyrazole photoswitch

Matsuo, Kazuya; Uehara, Ryota; Kikukawa, Takashi et al.

Chemical communications, 2024

Permalink : https://hdl.handle.net/2115/95389

このアイテムのアクセス数:167件（2026-08-12 09:41 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/95389
タイトル	Spatiotemporal regulation of CENP-E-guided chromosomes using a fast-relaxing arylazopyrazole photoswitch
著者	Matsuo, Kazuya ; Uehara, Ryota ; Kikukawa, Takashi ; Waku, Tomonori ; Kobori, Akio ; Tamaoki, Nobuyuki
e-Rad_Researcher 90764952 著者名 Matsuo, Kazuya
e-Rad_Researcher 20580020 著者名 Uehara, Ryota
e-Rad_Researcher 20281842 著者名 Kikukawa, Takashi
著者名 Waku, Tomonori
著者名 Kobori, Akio
e-Rad_Researcher 00344218 著者名 Tamaoki, Nobuyuki
言語	英語
発行日	2024-06-03
出版者	Royal Society of Chemistry
収録物名	Chemical communications
抄録	We developed a centromere-associated protein E (CENP-E) inhibitor employing trans to cis photoisomerization with 405 nm visible light illumination and fast thermal relaxation. This photoswitching characteristic of the inhibitor enabled selective blockage or release of the motion of particular chromosomes within a single mitotic cell. Using this technique, we successfully demonstrated targeted chromosome gain and loss in daughter cells by introducing asymmetric chromosome segregation. We developed a centromere-associated protein E (CENP-E) inhibitor employing trans to cis photoisomerization with 405 nm visible light illumination and fast thermal relaxation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1359-7345
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1039/d4cc01922a