Itaconate reduces proliferation and migration of fibroblast-like synoviocytes and ameliorates arthritis models

Tada, Maria; Kudo, Yuki; Kono, Michihito; Kanda, Masatoshi; Takeyama, Shuhei; Sakiyama, Kodai; Ishizu, Hotaka; Shimizu, Tomohiro; Endo, Tsutomu; Hisada, Ryo; Fujieda, Yuichiro; Kato, Masaru; Amengual, Olga; Iwasaki, Norimasa; Atsumi, Tatsuya

Itaconate reduces proliferation and migration of fibroblast-like synoviocytes and ameliorates arthritis models

Tada, Maria; Kudo, Yuki; Kono, Michihito et al.

Clinical immunology, 2024, 264, 110255

Permalink : https://hdl.handle.net/2115/95554

このアイテムのアクセス数:202件（2026-07-12 15:33 集計）

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Supplementary	pdf	594 KB	77	Supplementary data
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supplementary fig2	pdf	151 KB	46	Supplementary figure

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/95554
タイトル	Itaconate reduces proliferation and migration of fibroblast-like synoviocytes and ameliorates arthritis models
著者	Tada, Maria ; Kudo, Yuki ; Kono, Michihito ; Kanda, Masatoshi ; Takeyama, Shuhei ; Sakiyama, Kodai ; Ishizu, Hotaka ; Shimizu, Tomohiro ; Endo, Tsutomu ; Hisada, Ryo ; Fujieda, Yuichiro ; Kato, Masaru ; Amengual, Olga ; Iwasaki, Norimasa ; Atsumi, Tatsuya
著者名 Tada, Maria
著者名 Kudo, Yuki
e-Rad_Researcher 00835192 著者名 Kono, Michihito
著者名 Kanda, Masatoshi
著者名 Takeyama, Shuhei
著者名 Sakiyama, Kodai
著者名 Ishizu, Hotaka
e-Rad_Researcher 60784246 著者名 Shimizu, Tomohiro
e-Rad_Researcher 90805293 著者名 Endo, Tsutomu
著者名 Hisada, Ryo
e-Rad_Researcher 70790872 著者名 Fujieda, Yuichiro
著者名 Kato, Masaru
著者名 Amengual, Olga
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Rheumatoid arthritis
	Fibroblast-like synoviocytes
	Itaconate
	Intracellular metabolism
発行日	2024-05-18
出版者	Elsevier
収録物名	Clinical immunology
巻(号)	264
ページ	110255
抄録	Fibroblast-like synoviocytes (FLS) play critical roles in rheumatoid arthritis (RA). Itaconate (ITA), an endogenous metabolite derived from the tricarboxylic acid (TCA) cycle, has attracted attention because of its anti-inflammatory, antiviral, and antimicrobial effects. This study evaluated the effect of ITA on FLS and its potential to treat RA. ITA significantly decreased FLS proliferation and migration in vitro, as well as mitochondrial oxidative phosphorylation and glycolysis measured by an extracellular flux analyzer. ITA accumulates metabolites including succinate and citrate in the TCA cycle. In rats with type II collagen-induced arthritis (CIA), intra-articular injection of ITA reduced arthritis and bone erosion. Irg1-deficient mice lacking the ability to produce ITA had more severe arthritis than control mice in the collagen antibody-induced arthritis. ITA ameliorated CIA by inhibiting FLS proliferation and migration. Thus, ITA may be a novel therapeutic agent for RA.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1521-6616
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.clim.2024.110255