Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects

Igarashi, Saki; Hioki, Sayaka; Sakamaru, Naoto; Suzuki, Asahi; Kurokawa, Mihoko; Kato, Eisuke

Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects

Igarashi, Saki; Hioki, Sayaka; Sakamaru, Naoto et al.

Natural Product Research, 2024, 39(12), 3481-3485

Permalink : https://hdl.handle.net/2115/95579

このアイテムのアクセス数:142件（2026-07-15 01:51 集計）

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HUSCAP_DOI10.1080_14786419.2024.2340049	pdf	151 KB	112
HUSCAP_DOI10.1080_14786419.2024.2340049_suppl	pdf	4.22 MB	44

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/95579
タイトル	Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects
著者	Igarashi, Saki ; Hioki, Sayaka ; Sakamaru, Naoto ; Suzuki, Asahi ; Kurokawa, Mihoko ; Kato, Eisuke
著者名 Igarashi, Saki
著者名 Hioki, Sayaka
著者名 Sakamaru, Naoto
著者名 Suzuki, Asahi
著者名 Kurokawa, Mihoko
e-Rad_Researcher 40466446 著者名 Kato, Eisuke
言語	英語
キーワード	Vascular system
	cardiovascular disease
	TIE2
	catechin
	flavonoid
	anthocyanidin
	triterpenoid
発行日	2024-04-12
出版者	Taylor & Francis
収録物名	Natural Product Research
巻(号)	39(12)
ページ	3481-3485
抄録	Vascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase receptor expressed on vascular endothelial cells and contributes to the maintenance of a vascular system. In this paper, we screened for natural products with an activity to induce phosphorylation of TIE2, which will be beneficial for protection of a vascular system. Employing HeLa cells expressing TIE2, flavan-3-ols, flavonoids, anthocyanidins and triterpenoids were identified as active compounds that induce TIE2 phosphorylation. Several of the identified compounds are previously reported to protect endothelial cells from inflammation. Thus, the result provided TIE2 as the candidate receptor protein of those compounds for the protective effect of endothelial cells and the identified compounds will be a good candidate for maintenance of a vascular system.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 12 Apr 2024, available at: https://doi.org/10.1080/14786419.2024.2340049.
PISSN	1478-6419
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/14786419.2024.2340049