Boron-Catalyzed Michael Reaction of Donor-Acceptor Carboxylic Acid Pairs Enabling Direct Synthesis of 1,5-Dicarboxylic Acids

Yoshida, Yukiho; Sawamura, Masaya; Shimizu, Yohei

Boron-Catalyzed Michael Reaction of Donor-Acceptor Carboxylic Acid Pairs Enabling Direct Synthesis of 1,5-Dicarboxylic Acids

Yoshida, Yukiho; Sawamura, Masaya; Shimizu, Yohei

Organic letters, 2024, 26(26), 5425-5429

Permalink : https://hdl.handle.net/2115/95669

このアイテムのアクセス数:149件（2026-08-12 12:09 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/95669
タイトル	Boron-Catalyzed Michael Reaction of Donor-Acceptor Carboxylic Acid Pairs Enabling Direct Synthesis of 1,5-Dicarboxylic Acids
著者	Yoshida, Yukiho ; Sawamura, Masaya ; Shimizu, Yohei
著者名 Yoshida, Yukiho
e-Rad_Researcher 40202105 著者名 Sawamura, Masaya
e-Rad_Researcher 60609816 著者名 Shimizu, Yohei
言語	英語
発行日	2024-07-05
出版者	American Chemical Society
収録物名	Organic letters
巻(号)	26(26)
ページ	5425-5429
抄録	A boron-catalyzed Michael reaction using pairs of carboxylic acids was developed. The reaction occurs through dual activation of the two substrates by a boron catalyst, which facilitates boron enolate formation from the donor carboxylic acid with simultaneous activation of the alpha,beta-unsaturated carboxylic acid as the acceptor. alpha-Aryl and alpha-alkenyl carboxylic acids were applicable as donors. The versatility and utility of this reaction were demonstrated by the direct use of pharmaceuticals as donor carboxylic acids.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-9DKXPMVA8Z2BYXVNQCNQ
PISSN	1523-7060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.orglett.4c01542