Clinical outcome, radiological findings, and genetic features of IDH-mutant brainstem glioma in adults

Oki, Sogo; Ishi, Yukitomo; Sawaya, Ryosuke; Okamoto, Michinari; Motegi, Hiroaki; Tanei, Zen-ichi; Tsuda, Masumi; Mori, Takashi; Nishioka, Kentaro; Kanno-Okada, Hiromi; Aoyama, Hidefumi; Tanaka, Shinya; Yamaguchi, Shigeru; Fujimura, Miki

Clinical outcome, radiological findings, and genetic features of IDH-mutant brainstem glioma in adults

Oki, Sogo; Ishi, Yukitomo; Sawaya, Ryosuke et al.

Acta neurochirurgica, 2024, 166(1), 263

Permalink : https://hdl.handle.net/2115/95678

このアイテムのアクセス数:171件（2026-07-12 05:34 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/95678
タイトル	Clinical outcome, radiological findings, and genetic features of IDH-mutant brainstem glioma in adults
著者	Oki, Sogo ; Ishi, Yukitomo ; Sawaya, Ryosuke ; Okamoto, Michinari ; Motegi, Hiroaki ; Tanei, Zen-ichi ; Tsuda, Masumi ; Mori, Takashi ; Nishioka, Kentaro ; Kanno-Okada, Hiromi ; Aoyama, Hidefumi ; Tanaka, Shinya ; Yamaguchi, Shigeru ; Fujimura, Miki
著者名 Oki, Sogo
e-Rad_Researcher 30812284 著者名 Ishi, Yukitomo
著者名 Sawaya, Ryosuke
著者名 Okamoto, Michinari
著者名 Motegi, Hiroaki
著者名 Tanei, Zen-ichi
著者名 Tsuda, Masumi
著者名 Mori, Takashi
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
著者名 Kanno-Okada, Hiromi
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
著者名 Yamaguchi, Shigeru
e-Rad_Researcher 00361098 著者名 Fujimura, Miki
言語	英語
キーワード	IDH-mutant
	Brainstem
	Glioma
	Astrocytoma
	DIPG
	MRI
発行日	2024-06-12
出版者	Springer
収録物名	Acta neurochirurgica
巻(号)	166(1)
ページ	263
抄録	Background With the recent advent of genetic testing, IDH-mutant glioma has been found among adult brainstem gliomas. However, the clinical outcome and prognosis of IDH-mutant brainstem gliomas in adults have not been elucidated. This study aimed to investigate the clinical outcome, radiological findings, and genetic features of adult patients with IDH-mutant diffuse brainstem gliomas. Methods Data from adult patients with brainstem glioma at Hokkaido University Hospital between 2006 and 2022 were retrospectively analyzed. Patient characteristics, treatment methods, genetic features, and prognosis were evaluated. Results Of 12 patients with brainstem glioma with proven histopathology, 4 were identified with IDH mutation. All patients underwent local radiotherapy with 54 Gray in 27 fractions combined with chemotherapy with temozolomide. Three patients had IDH1 R132H mutation and one had IDH2 R172G mutation. The median progression-free survival and overall survival were 68.4 months and 85.2 months, respectively, longer than that for IDH-wildtype gliomas (5.6 months and 12.0 months, respectively). At the time of initial onset, contrast-enhanced lesions were observed in two of the four cases in magnetic resonance imaging. Conclusion As some adult brainstem gliomas have IDH mutations, and a clearly different prognosis from those with IDH-wildtype, biopsies are proactively considered to confirm the genotype.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00701-024-06154-3
PISSN	0001-6268
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00701-024-06154-3