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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/95772
タイトル	Photoswitchable Auxin-Inducible Degron System for Conditional Protein Degradation with Spatiotemporal Resolution
著者	Sahu, Saugata ; Yoshizawa, Koya ; Yamamoto, Takahiro ; Uehara, Ryota ; Tamaoki, Nobuyuki
著者名 Sahu, Saugata
著者名 Yoshizawa, Koya
著者名 Yamamoto, Takahiro
e-Rad_Researcher 20580020 著者名 Uehara, Ryota
e-Rad_Researcher 00344218 著者名 Tamaoki, Nobuyuki
言語	英語
発行日	2024-07-24
出版者	American Chemical Society
収録物名	Journal of the American Chemical Society
巻(号)	146(31)
ページ	21203-21207
抄録	The auxin-inducible degron (AID) system degrades target proteins rapidly in a controllable manner. Although this is a highly versatile technique for studying protein functionality, protein degradation with spatiotemporal resolution is not currently possible. Herein we describe a photoswitchable AID using a light-active auxin derivative for reversible and site-specific protein degradation with temporal resolution.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-BITHBPYJPBHUITZPE46I.
PISSN	0002-7863
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/jacs.4c05135

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