Epidemiology and molecular characterization of Mycobacterium tuberculosis including a drug-resistant strain associated with mortality of Asian elephants in Nepal 2019-2022

Pandit, Arjun; Thapa, Jeewan; Sadaula, Amir; Suzuki, Yasuhiko; Nakajima, Chie; Mikota, Susan K.; Subedi, Naresh; Shrestha, Bijaya Kumar; Shimozuru, Michito; Shrestha, Bhawana; Raya, Bijendra; Chaudhary, Sanjay; Paudel, Sarad; Tsubota, Toshio

Epidemiology and molecular characterization of Mycobacterium tuberculosis including a drug-resistant strain associated with mortality of Asian elephants in Nepal 2019-2022

Pandit, Arjun; Thapa, Jeewan; Sadaula, Amir et al.

Tuberculosis, 2024, 148, 102550

Permalink : https://hdl.handle.net/2115/95870

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アクセス権	open access
URI	https://hdl.handle.net/2115/95870
タイトル	Epidemiology and molecular characterization of Mycobacterium tuberculosis including a drug-resistant strain associated with mortality of Asian elephants in Nepal 2019-2022
著者	Pandit, Arjun ; Thapa, Jeewan ; Sadaula, Amir ; Suzuki, Yasuhiko ; Nakajima, Chie ; Mikota, Susan K. ; Subedi, Naresh ; Shrestha, Bijaya Kumar ; Shimozuru, Michito ; Shrestha, Bhawana ; Raya, Bijendra ; Chaudhary, Sanjay ; Paudel, Sarad ; Tsubota, Toshio
著者名 Pandit, Arjun
e-Rad_Researcher 40837449 著者名 Thapa, Jeewan
著者名 Sadaula, Amir
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
著者名 Mikota, Susan K.
著者名 Subedi, Naresh
著者名 Shrestha, Bijaya Kumar
e-Rad_Researcher 50507168 著者名 Shimozuru, Michito
著者名 Shrestha, Bhawana
著者名 Raya, Bijendra
著者名 Chaudhary, Sanjay
著者名 Paudel, Sarad
e-Rad_Researcher 10207441 著者名 Tsubota, Toshio
言語	英語
キーワード	Elephant
	Tuberculosis
	Nepal
	Genotyping
	Transmission dynamics
発行日	2024-07-30
出版者	Elsevier
収録物名	Tuberculosis
巻(号)	148
ページ	102550
抄録	Tuberculosis (TB) is an emerging threat to the survival of elephants in Nepal. We investigated the lung tissue samples from nine elephants that died from 2019 to 2022 in Nepal using culture, conventional PCR, and loopmediated isothermal amplification (LAMP) and then performed genotyping of five PCR-positive isolates to understand the possible transmission dynamics of Mycobacterium tuberculosis (Mtb). Results showed that two-thirds (6/9) of elephants were confirmed to be infected from Mtb by LAMP, 5/9 by PCR, and 4/9 by culture. Genotyping of Mtb isolates showed that elephants were infected with the Indo-Oceanic and Beijing lineages including an isoniazid-resistant Beijing lineage. MIRU-VNTR-based phylogeny, gyrA, and katG sequencing showed the possibility of ongoing transmission of Indo-Oceanic lineages and likely transmission of the drug-resistant Beijing lineage from human to elephant. Implementation of comprehensive surveillance and preventive measures are urgently needed to address this zoonotic disease and protect elephants from TB in Nepal.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1472-9792
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tube.2024.102550