open access

https://hdl.handle.net/2115/95885

Rational design of dual Chemo- and Thermo-responsive phase separation of Poly(4-hydroxystyrene) in non-aqueous media

英語

2025-02

Springer Nature

Polymer journal

57(2)

181-188

Dual stimuli-responsiveness in non-aqueous media could allow various molecular designs using a system that is not compatible with aqueous media. However, the difficulty in controlling the desolvation of the polymer chains in non-aqueous media for lower critical solution temperature (LCST)-type phase separation at ambient temperature has hindered the attainment of dual stimuli-responsiveness based on chemical stimuli. In this study, we rationally designed dual chemo- and thermo-responsive phase separations of poly(4-hydroxystyrene) in non-aqueous media. The LCST-type thermo-responsiveness of poly(4-hydroxystyrene) in 1,4-dioxane/toluene was considerably altered by the addition of small amounts of hydrogen-bonding molecules as chemical stimuli. Secondary amines or molecules containing two hydrogen-bonding functional groups formed stronger hydrogen bonds with the polymer chains than 1,4-dioxane, which altered the solvation state and induced the UCST-type thermo-responsiveness or insolubility of PHS. This dual stimuli-responsive system could serve as a chemical sensor to detect the presence of acids. Dual chemo- and thermo-responsive phase separations of poly(4-hydroxystyrene) in non-aqueous media were demonstrated. The addition of small amounts of hydrogen-bonding molecules as chemical stimuli caused a considerable change of LCST-type thermo-responsiveness of poly(4-hydroxystyrene) in 1,4-dioxane/toluene. Secondary amines or molecules containing two hydrogen-bonding functional groups could cross-link the polymer chains through the hydrogen bonds, which altered the solvation state and induced the UCST-type thermo-responsiveness or insolubility of the polymer. This dual stimuli-responsive system worked as a chemical sensor to detect the presence of acids.

学術雑誌論文

Accepted Manuscript

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41428-024-00968-9

0032-3896