Relationship between magnesium dosage and the preventive effect on cisplatin-induced nephrotoxicity: meta-analysis and meta-regression analysis

Okamoto, Keisuke; Saito, Yoshitaka; Yamaguchi, Atsushi; Narumi, Katsuya; Kobayashi, Masaki

Relationship between magnesium dosage and the preventive effect on cisplatin-induced nephrotoxicity: meta-analysis and meta-regression analysis

Okamoto, Keisuke; Saito, Yoshitaka; Yamaguchi, Atsushi et al.

International journal of clinical oncology, 2024, 29, 1817-1824

Permalink : https://hdl.handle.net/2115/96014

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アクセス権	open access
URI	https://hdl.handle.net/2115/96014
タイトル	Relationship between magnesium dosage and the preventive effect on cisplatin-induced nephrotoxicity: meta-analysis and meta-regression analysis
著者	Okamoto, Keisuke ; Saito, Yoshitaka ; Yamaguchi, Atsushi ; Narumi, Katsuya ; Kobayashi, Masaki
著者名 Okamoto, Keisuke
e-Rad_Researcher 00835001 著者名 Saito, Yoshitaka
著者名 Yamaguchi, Atsushi
e-Rad_Researcher 90746752 著者名 Narumi, Katsuya
e-Rad_Researcher 70431319 著者名 Kobayashi, Masaki
言語	英語
キーワード	Cisplatin
	Magnesium
	Cisplatin-induced nephrotoxicity
	Meta-analysis
	Meta-regression analysis
	Diuretic drugs
発行日	2024-09-24
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	29
ページ	1817-1824
抄録	Background Cisplatin (CDDP) is an anticancer drug used to treat several types of cancer. CDDP-induced nephrotoxicity (CIN) is a serious adverse effect of CDDP treatment. Although magnesium sulfate (Mg) premedication has been proven to prevent CIN, the relationship between Mg dosage and its preventive effects on CIN are unknown. Therefore, we have evaluated this relationship using meta-analysis and meta-regression analysis to optimize cancer chemotherapies, including CDDP. Methods We selected candidate studies, generated a forest plot to evaluate the preventive effects of Mg on CIN, and performed subgroup analyses. Moreover, a meta-regression analysis was conducted to reveal the relationship between Mg dosage and its preventive effects on CIN. Results We identified 17 related studies and the total odds ratio (OR) of Mg premedication on CIN was 0.26 and the 95% confidence interval (95% CI) was 0.17-0.41 (p < 0.00001) although funnel plot suggested asymmetry. In subgroup analysis by forest plot, total OR with 95% CI of low Mg dosage administration (less than 10 mEq) and high Mg dosage administration (10 mEq or higher) was 0.35 (0.16-0.77, p = 0.0169) and 0.12 (0.07-0.21, p < 0.0001), respectively. In addition, meta-regression analysis was performed on Mg dosage and the OR of related studies, indicating a relationship between Mg dosage and OR (p = 0.0349). Conclusion This study has revealed that premedication with Mg prevented CIN in a dose-dependent manner.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/https://doi.org/10.1007/s10147-024-02629-6
PISSN	1341-9625
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-024-02629-6