Mitochondrial DNA copy numbers in gastric cancer tissues : a possible biomarker for estimating cancer progression

Fukunaga, Hisanori; Fukunaga, Mayuko

Japanese Journal of Clinical Oncology, 2025, 55(8), 920-924

Permalink : https://hdl.handle.net/2115/96124

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アクセス権
open access
URI
https://hdl.handle.net/2115/96124
タイトル
Mitochondrial DNA copy numbers in gastric cancer tissues : a possible biomarker for estimating cancer progression
著者
e-Rad_Researcher
50781267
著者名
Fukunaga, Hisanori
著者名
Fukunaga, Mayuko
言語
英語
キーワード
Biomarker
DNA copy number variation
Gastric cancer
Mitochondrial DNA
Tumor stage
発行日
2025-04-23
出版者
Oxford University Press
収録物名
Japanese Journal of Clinical Oncology
巻(号)
55(8)
ページ
920-924
抄録
Background Mitochondria have their own genome (mtDNA), which in humans is a circular multi-copy genome consisting of 16 569 base pairs. Abnormalities in the mtDNA have been reported to correlate with various age-related pathophysiologies. Methods Based on a total of 182 DNA samples extracted from gastric cancer tissues, we measured mtDNA copy numbers (mtDNA-CN) using real-time polymerase chain reaction (PCR) and then examined alongside sex, age, tumor stage, Laurén classification, and the overexpression of Human Epidermal Growth Factor Receptor 2 (HER2). Results We found no sex differences in mtDNA-CN and no correlation with age, but significant differences according to tumor stage. The mtDNAcn of intestinal type by Laurén classification was significantly larger than that of diffuse type. There was no significant difference in mtDNA-CN between HER2-positive and -negative tissues. Multiple regression analyses showed that only the tumor stage was a significant variable, while Laurén classification was not. Conclusion These results indicate that mitochondrial genomic abnormalities contribute the progression of gastric cancer independently of HER2 overexpression, and may shed light on the emerging role of mtDNA-CN in situ as a possible biomarker for estimating cancer progression.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record Hisanori Fukunaga, Mayuko Fukunaga, Mitochondrial DNA copy numbers in gastric cancer tissues: a possible biomarker for estimating cancer progression, Japanese Journal of Clinical Oncology, Volume 55, Issue 8, August 2025, Pages 920–924 is available online at: https://doi.org/10.1093/jjco/hyaf066
PISSN
1465-3621
NCID
AA12052404
関連情報
PMID
40263745
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1093/jjco/hyaf066