π-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy

Zhao, Hanjun; Naganawa, Rina; Yamada, Yuma; Osakada, Yasuko; Fujitsuka, Mamoru; Mitomo, Hideyuki; Miyatake, Yukiko; Harashima, Hideyoshi; Biju, Vasudevanpillai; Takano, Yuta

π-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy

Zhao, Hanjun; Naganawa, Rina; Yamada, Yuma et al.

Journal of photochemistry and photobiology a-chemistry, 2024, 449, 115397

Permalink : https://hdl.handle.net/2115/97071

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アクセス権	open access
URI	https://hdl.handle.net/2115/97071
タイトル	π-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy
著者	Zhao, Hanjun ; Naganawa, Rina ; Yamada, Yuma ; Osakada, Yasuko ; Fujitsuka, Mamoru ; Mitomo, Hideyuki ; Miyatake, Yukiko ; Harashima, Hideyoshi ; Biju, Vasudevanpillai ; Takano, Yuta
著者名 Zhao, Hanjun
著者名 Naganawa, Rina
e-Rad_Researcher 60451431 著者名 Yamada, Yuma
著者名 Osakada, Yasuko
著者名 Fujitsuka, Mamoru
e-Rad_Researcher 50564952 著者名 Mitomo, Hideyuki
e-Rad_Researcher 10421984 著者名 Miyatake, Yukiko
e-Rad_Researcher 00183567 著者名 Harashima, Hideyoshi
著者名 Biju, Vasudevanpillai
著者名 Takano, Yuta
言語	英語
キーワード	Reactive oxygen species
	Singlet oxygen
	Cancer therapy
	Phototherapy
	Pi-conjugation
発行日	2024-04-01
出版者	Elsevier
収録物名	Journal of photochemistry and photobiology a-chemistry
巻(号)	449
ページ	115397
抄録	Near-infrared (NIR) photosensitizers have great potential to develop various fields of photochemistry, such as photodynamic therapy (PDT) and photocatalysts. Organelle-targeted PDT using NIR light attracts considerable attention to high-efficiency phototherapy. Although drug delivery system (DDS) carriers are often combined with NIR photosensitizers for effective PDT, the systematic correlations between the cargo and DDS carriers are still unclear. In this study, we develop NIR-photosensitizers from a pi-extended porphyrin-type sensitizer (rTPA) that allows us to modify the structure and properties with a one-touch operation for the systematic study. Single-step amidations give five rTPA derivatives readily, facilitating comprehensive information about the properties according to their molecular structure and electric charge of the photosensitizer and DDS carriers prepared using a microfluidic device. One of the combinations, rTPA-NH2@MP, demonstrates the highest ability among the derivatives to kill pancreatic cancer cells, which are known to be highly lethal. The present study provides a guideline for inventing effective DDS-based NIR-PDT compounds for future photodrugs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1010-6030
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jphotochem.2023.115397