Comparison of busulfan pharmacokinetics between four-times-daily and once-daily administration in pediatric patients : a preliminary prospective observational trial

Yamaguchi, Atsushi; Hirabayashi, Shinsuke; Niki, Kazuko; Kagami, Keisuke; Terashita, Yukayo; Cho, Yuko; Manabe, Atsushi; Sugawara, Mitsuru; Takekuma, Yoh

Comparison of busulfan pharmacokinetics between four-times-daily and once-daily administration in pediatric patients : a preliminary prospective observational trial

Yamaguchi, Atsushi; Hirabayashi, Shinsuke; Niki, Kazuko et al.

International journal of hematology, 2024, 121(2), 244-251

Permalink : https://hdl.handle.net/2115/97337

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アクセス権	open access
URI	https://hdl.handle.net/2115/97337
タイトル	Comparison of busulfan pharmacokinetics between four-times-daily and once-daily administration in pediatric patients : a preliminary prospective observational trial
著者	Yamaguchi, Atsushi ; Hirabayashi, Shinsuke ; Niki, Kazuko ; Kagami, Keisuke ; Terashita, Yukayo ; Cho, Yuko ; Manabe, Atsushi ; Sugawara, Mitsuru ; Takekuma, Yoh
著者名 Yamaguchi, Atsushi
e-Rad_Researcher 50769635 著者名 Hirabayashi, Shinsuke
e-Rad_Researcher 50447645 著者名 Niki, Kazuko
著者名 Kagami, Keisuke
著者名 Terashita, Yukayo
著者名 Cho, Yuko
e-Rad_Researcher 20292849 著者名 Manabe, Atsushi
e-Rad_Researcher 60332467 著者名 Sugawara, Mitsuru
e-Rad_Researcher 00396293 著者名 Takekuma, Yoh
言語	英語
キーワード	Busulfan
	Hematopoietic stem cell transplantation
	Test dose
	Therapeutic drug monitoring
	Pharmacokinetics
発行日	2024-12-03
出版者	Springer
収録物名	International journal of hematology
巻(号)	121(2)
ページ	244-251
抄録	Therapeutic drug monitoring (TDM) of busulfan (BU) is useful for achieving the target area under the curve (AUC) because its effective plasma-concentration range is narrow. This preliminary observational study evaluated the pharmacokinetic (PK) parameters of BU administered four times daily or once daily to pediatric patients. The plasma concentrations were measured at both the test dose and first dose, and the doses on day 1 and days 2–4 were determined based on each TDM. A comparison of PK parameters between four-times-daily and once-daily administration was performed for both the test dose and first dose of BU. Of the 11 patients, five received four-times-daily BU and six received once-daily BU. The Vd for once-daily administration was higher than that for four-times-daily administration for the first dose but not for the test dose. The ratio of actual AUC for the first dose to estimated AUC guided by the test dose was lower with once-daily administration than with four-times-daily administration. These results indicate that the PK parameters of BU administered once daily are challenging to predict based on the TDM of the test dose. TDM should be considered on day 1 to achieve the target AUC, especially with once-daily administration.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12185-024-03891-0
PISSN	0925-5710
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12185-024-03891-0